The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Preclinical overview of nabumetone. Pharmacology, bioavailability, metabolism, and toxicology.

Nabumetone is a novel nonacidic nonsteroidal anti-inflammatory drug (NSAID) developed by Beecham Pharmaceuticals. After absorption, nabumetone undergoes extensive metabolism, the main circulating material being 6-methoxy-2-naphthylacetic acid, (BRL 10720). This, unlike nabumetone, is a potent inhibitor of prostaglandin synthesis and is considered to be the active anti-inflammatory metabolite. Nabumetone is active in all standard laboratory models of inflammation and has a greater ratio of active to gastric irritant doses (therapeutic ratio) in the rat than any other NSAID tested. The lack of effect on the gastric mucosa in all species has been a notable feature of the toxicology studies. In humans, relative bioavailability is similar after administration of different dose levels, the mean terminal plasma half-life of BRL 10720 being about 24 hours, allowing for once-daily dosing. The half-life of BRL 10720 does not change on repeated dosing, and no unexpected or irreversible accumulation occurs in elderly patients.[1]


WikiGenes - Universities