The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

About

Terms

 

 
 
 
 

Differential responses of synaptosomal cation movements and respiration to the convulsants penicillin, pentylenetetrazol and 3-aminopyridine.

The effect of three convulsants was tested in rat cortical synaptosomes by measuring Na+ and K+ movements and respiration. Penicillin (of its derivatives the 3-phenyl-5-methyl-4-isoxazolyl-penicillin, i.e. oxacillin was used) at 2 to 14 mM concentration prolonged the uptake phase of the K+-curve without altering final cation equilibrium. Pentylenetetrazol, at 10 to 50 mM exerted a concentration-dependent inhibitory effect on K+-uptake, while 3-aminopyridine was effective only at high concentrations (50 mM) preventing synaptosomal K+-uptake and increasing the synaptosomal Na+-content without, however, blocking respiration. The data suggest a transitional rise of K+-permeability of synaptosomal membrane in the presence of oxacillin, without lasting depolarization. Sufficient doses of 3-aminopyridine probably depolarize synaptosomes, the underlying mechanism probably being associated with the primary blocking of K+-channels and a subsequent increase in Na+ influx rather than with the inhibition of the Na+--K+-pump.[1]

References

  1. Differential responses of synaptosomal cation movements and respiration to the convulsants penicillin, pentylenetetrazol and 3-aminopyridine. Csillag, A., Kittel, A., Kálmán, M. Acta physiologica Hungarica. (1986) [Pubmed]
Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities