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Chemical Compound Review

Corazole     1,8,9,10- tetrazabicyclo[5.3.0]deca- 7,9-diene

Synonyms: Korazole, Metrazol, Pentazol, Cardiazol, Corasol, ...
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Disease relevance of Corazol


Psychiatry related information on Corazol


High impact information on Corazol


Chemical compound and disease context of Corazol


Biological context of Corazol

  • The M1 muscarinic receptor antagonist pirenzepine in low doses decreases resting heart rate; this effect declines with age (Poller, U., G. Nedelka, J. Radke, K. Pönicke, and O.-E. Brodde. 1997. J. Am. Coll. Cardiol. 29:187-193) [21].
  • Conversely, the convulsant agents pentylenetetrazol and picrotoxin each caused an increase in the state of phosphorylation of these proteins [22].
  • The mice show a reduction in the duration and severity of seizures induced by kainate or pentylenetetrazole, and both necrosis and apoptosis of hippocampal neurons are prevented [23].
  • To discriminate between events that are products of the seizures elicited by KA and those that are specifically associated with its neurotoxic actions, we have examined the expression of cellular immediate-early genes (cIEGs) following KA or pentylenetetrazol (PTZ) treatment in c-fos-lacZ transgenic rats [24].
  • This phenotype is maintained on two different strain backgrounds, is rescued by transgenic expression of Thy-1 and by administration of the GABA(A) receptor antagonist pentylenetetrazole [25].

Anatomical context of Corazol

  • Administration of the convulsants pentylenetetrazole (Metrazole) or picrotoxin to rats caused a dramatic increase in mRNAs of four putative transcription factor genes, zif/268, c-jun, jun-B, and c-fos, in neurons of the hippocampus and dentate gyrus, as well as other areas of the cerebral cortex, including pyriform cortex and cingulate cortex [26].
  • We found that nur77 and nurr-1 are induced in the adrenal gland upon treatment with pentylene tetrazole (Ptz; Metrazole) [27].
  • RNA blot analysis demonstrates that NGFI-C mRNA is induced within minutes of stimulation of PC12 cells by nerve growth factor and is similarly activated in brain after a Metrazol-induced seizure [28].
  • Microvessels were isolated by albumin flotation and glass bead filtration from cerebral cortices of gerbils decapitated during pentylenetetrazol (PTZ)-induced seizures and ischemia-induced seizures [29].
  • Metrazole-stimulated seizure activity triggers rapid (<1 h) but transient up-regulation of MKP-3 mRNA in the cortex, piriform cortex, and some amygdala nuclei [30].

Associations of Corazol with other chemical compounds


Gene context of Corazol


Analytical, diagnostic and therapeutic context of Corazol


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