Disease relevance of pyridin-3-amine

• The antibacterial activity of 3-aminopyridine riboside was found to be specific for H. influenzae but had no effect on the growth of Staphylococcus aureus or Escherichia coli [1].
• In an in vivo microdialysis study, we measured the extracellular changes of nucleoside and amino acid levels and recorded cortical EEG during 3-aminopyridine-induced epilepsy [2].
• We also tested other species of the family Pasteurellaceae, Pasteurella multocida and Actinobacillus actinomycetemcomitans, and found that 3-aminopyridine riboside does not act as a growth inhibitor; hence, 3-aminopyridine riboside represents an anti-infective agent with a very narrow host range [3].

High impact information on pyridin-3-amine

• Intradendritic records indicate that the electroresponsive properties of the dendrites linger after voltage-dependent sodium and potassium conductances are reduced by superfusion of the cortex with Ringer's solution containing 20 mug/ml tetrodotoxin and 5 mM 3-aminopyridine [4].
• 3-Aminopyridine riboside is utilized effectively in a pnuC+ background [3].
• 3-Aminopyridine riboside-resistant H. influenzae isolates were characterized, and mutations in nadR could be detected [3].
• In additional experiments by reversed-phase high-performance liquid chromatography, it was determined that whole cells of H. influenzae degrade 3-aminopyridine adenine dinucleotide to 3-aminopyridine riboside, which is then internalized [1].
• 2. In the presence of tetraethylammonium (TEA) or 3-aminopyridine (3-AP), but not in their absence, Ca dependent action potentials could be evoked with depolarizing current pulses in the somatic, axonal, and terminal regions [5].

Biological context of pyridin-3-amine

• The effects of 3-aminopyridine (3-AP) on synaptic transmission in bullfrog sympathetic ganglion were studied in normal Ringer's solution and during graded reductions in extracellular Ca++ by means of intra- and extracellular recording techniques [6].
• The method is based on the coupling of the hydrolysis product of propoxur with diazotized 3-aminopyridine in an alkaline medium, to form an azo-dye which has a maximum absorbance at 463 nm [7].

Anatomical context of pyridin-3-amine

• Calcium-dependent action potentials were recorded from mouse spinal cord neurons in primary dissociated cell culture following addition of the potassium channel blockers tetraethylammonium ion and 3-aminopyridine [8].
• Effects of 3-aminopyridine (3-Ap) applied intracellularly into electrophysiologically identified cortical neurons in the cat motor cortex were studied [9].
• Sufficient doses of 3-aminopyridine probably depolarize synaptosomes, the underlying mechanism probably being associated with the primary blocking of K+-channels and a subsequent increase in Na+ influx rather than with the inhibition of the Na+--K+-pump [10].
• Early ultrastructural changes in the cerebral cortex of albino rats subjected to 3-aminopyridine seizures [11].
• 3-Aminopyridine (3-AP, 1 mM), which is a relatively poor inhibitor of voltage-dependent K+ channels, depolarized smooth muscle cells in the arteries by 1 mV [12].

Associations of pyridin-3-amine with other chemical compounds

• Preparation and single-crystal X-ray structure determination of three co-crystals of hydrogen squarate, HSQ(-), with 2-aminopyrimidine, 3-aminopyridine and 4-aminopyridine, and one of squarate, SQ(2-), with 8-aminoquinoline are reported [13].
• The experimental data were recorded from cat cortex treated with 3-Aminopyridine (3-Ap) by glass microelectrodes during nembutal anesthesia [14].
• Treatment of 3-aminopyridine adenine dinucleotide phosphate with sodium periodate in the neutral pH resulted in oxidation of the ribose linked to 3-aminopyridine and cleavage of the dinucleotide into adenosine- and 3-aminopyridine-containing moieties [15].
• Interestingly, quadruple type hydrogen bonding patterns are seen in cocrystals containing 3-aminopyridine or ethanol and water, while a network of acyclic tetrahedral pentamers of water is found in the cocrystal containing diazabicyclo [2.2.2]octane and water [16].
• Comparative studies on the reactivity of the heterocyclic nitrogen were carried out for pyridine and its three monosubstituted derivatives 2-aminopyridine (2-AP), 3-aminopyridine (3-AP), and 4-aminopyridine (4-AP) to reveal the structural basis for the differences in their susceptibility to N-oxidation [17].

Gene context of pyridin-3-amine

• Studies of yeast alcohol dehydrogenase with 3-aminopyridine monucleotide [18].

References