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Chemical Compound Review

AGN-PC-00K6HT     3,3-dimethyl-6-[(5-methyl-3- phenyl-1,2...

Synonyms: SureCN14126543, Oprea1_168564, Oprea1_662776, AC1L1IJP, CTK4B0244, ...
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Disease relevance of oxacillin


Psychiatry related information on oxacillin


High impact information on oxacillin


Chemical compound and disease context of oxacillin


Biological context of oxacillin

  • Mutants with the blue epsilon phenotype differed from gold epsilon parents in a variety of phenotypic properties, including increased resistance to oxacillin [15].
  • MBC and kill kinetics tests were both performed using Mueller-Hinton broth (MHB), with and without 2% NaCl supplementation, and incubation at 30 and 35 degrees C. When MBC testing was performed with salt-supplemented MHB, the oxacillin MBC/MIC ratio was greater than 8 for 17 and 16 of 17 S. aureus isolates at 30 and 35 degrees C, respectively [16].
  • The type II penicillinase (oxacillin-hydrolyzing beta-lactamase, OXA-1) gene on plasmid Rms213 was transposed to various plasmids or to the host chromosome [17].
  • Moreover, detection of IS256 was found to be associated with biofilm formation and the presence of the icaADBC operon as well as with gentamicin and oxacillin resistance in the clinical strains [18].
  • In 1992 and 1993, at The Ohio State University Medical Center, a larger proportion of Staphylococcus epidermidis strains required oxacillin MICs of 1 to 2 micrograms/ml than did Staphylococcus aureus strains. mecA genotype was correlated with antimicrobial susceptibility for selected clinical S. epidermidis strains [19].

Anatomical context of oxacillin


Associations of oxacillin with other chemical compounds

  • Covalent complexes with benzylpenicillin and oxacillin provide evidence that serine acylation does not entail significant structural changes, thus supporting the hypothesis that additional extracellular segments of MecR1 are involved in signal transmission [24].
  • Ampicillin and oxacillin were administered by either repeated intramuscular injection of 30 mg/kg every 4 h or by constant infusion of 7.5 mg/kg per h for 24 h [25].
  • All S. aureus isolates (54.2% oxacillin resistant) were susceptible to linezolid (MIC90 = 2 microg/ml); MIC distributions were consistent, regardless of oxacillin or multidrug resistance status [26].
  • The spectrum of activity of the ketolide was most similar to that of clindamycin versus staphylococci and streptococci and superior to those of all macrolides tested against oxacillin-resistant staphylococci and vancomycin-resistant (vanA, vanB, and vanC) enterococcal isolates [27].
  • Cloxacillin and oxacillin hydrolysis was noticeable with the partially purified OXA-18 [28].

Gene context of oxacillin


Analytical, diagnostic and therapeutic context of oxacillin


  1. Molecular analysis of nosocomial infection by oxacillin-resistant Staphylococcus aureus lacking protein A and clumping factor. Schwarzkopf, A., Schmidt-Rotte, H., Schmidt, H., Kunz, E., Karch, H., Heesemann, J. Lancet (1992) [Pubmed]
  2. A prospective randomized trial evaluating prophylactic antibiotics to prevent triple-lumen catheter-related sepsis in patients treated with immunotherapy. Bock, S.N., Lee, R.E., Fisher, B., Rubin, J.T., Schwartzentruber, D.J., Wei, J.P., Callender, D.P., Yang, J.C., Lotze, M.T., Pizzo, P.A. J. Clin. Oncol. (1990) [Pubmed]
  3. Oxacillin hepatitis. Two patients with liver biopsy, and review of the literature. Bruckstein, A.H., Attia, A.A. Am. J. Med. (1978) [Pubmed]
  4. Association of teichoic acid antibody with metastatic sequelae of catheter-associated Staphylococcus aureus bacteremia: a failure of the two-week antibiotic treatment. Bernhardt, L.L., Antopol, S.C., Simberkoff, M.S., Rahal, J.J. Am. J. Med. (1979) [Pubmed]
  5. Hepatitis associated with high-dose oxacillin therapy. Pollock, A.A., Berger, S.A., Simberkoff, M.S., Rahal, J.J. Arch. Intern. Med. (1978) [Pubmed]
  6. Pneumococcal resistance to antibiotics. Klugman, K.P. Clin. Microbiol. Rev. (1990) [Pubmed]
  7. High level oxacillin and vancomycin resistance and altered cell wall composition in Staphylococcus aureus carrying the staphylococcal mecA and the enterococcal vanA gene complex. Severin, A., Tabei, K., Tenover, F., Chung, M., Clarke, N., Tomasz, A. J. Biol. Chem. (2004) [Pubmed]
  8. Recruitment of penicillin-binding protein PBP2 to the division site of Staphylococcus aureus is dependent on its transpeptidation substrates. Pinho, M.G., Errington, J. Mol. Microbiol. (2005) [Pubmed]
  9. Oral antibiotic treatment of right-sided staphylococcal endocarditis in injection drug users: prospective randomized comparison with parenteral therapy. Heldman, A.W., Hartert, T.V., Ray, S.C., Daoud, E.G., Kowalski, T.E., Pompili, V.J., Sisson, S.D., Tidmore, W.C., vom Eigen, K.A., Goodman, S.N., Lietman, P.S., Petty, B.G., Flexner, C. Am. J. Med. (1996) [Pubmed]
  10. Bilateral deep brachial vein thrombophlebitis due to vibrio fetus. Vesely, D., MacIntyre, S., Ratzan, K.R. Arch. Intern. Med. (1975) [Pubmed]
  11. Synergy of levofloxacin (L-ofloxacin) and oxacillin against quinolone-resistant Staphylococcus aureus, measured by the time-kill method. Patel, J.A., Pachucki, C.T., Lentino, J.R. Antimicrob. Agents Chemother. (1993) [Pubmed]
  12. Lack of in vitro efficacy of oral forms of certain cephalosporins, erythromycin, and oxacillin against Pasteurella multocida. Goldstein, E.J., Citron, D.M., Richwald, G.A. Antimicrob. Agents Chemother. (1988) [Pubmed]
  13. Resistance of Staphylococcus aureus to semisynthetic penicillins and cephalothin. Richmond, A.S., Simberkoff, M.S., Schaefler, S., Rahal, J.J. J. Infect. Dis. (1977) [Pubmed]
  14. Antagonism between nafcillin or oxacillin and rifampin against Staphylococcus aureus. Watanakunakorn, C., Tisone, J.C. Antimicrob. Agents Chemother. (1982) [Pubmed]
  15. Colonial morphology of staphylococci on Memphis agar: phase variation of slime production, resistance to beta-lactam antibiotics, and virulence. Christensen, G.D., Baddour, L.M., Madison, B.M., Parisi, J.T., Abraham, S.N., Hasty, D.L., Lowrance, J.H., Josephs, J.A., Simpson, W.A. J. Infect. Dis. (1990) [Pubmed]
  16. Bactericidal activity of oxacillin against beta-lactamase-hyperproducing Staphylococcus aureus. Woods, G.L., Yam, P. Antimicrob. Agents Chemother. (1988) [Pubmed]
  17. Tn2011, a new transposon encoding oxacillin-hydrolyzing beta-lactamase. Nakazawa, H., Mitsuhashi, S. Antimicrob. Agents Chemother. (1983) [Pubmed]
  18. The bacterial insertion sequence element IS256 occurs preferentially in nosocomial Staphylococcus epidermidis isolates: association with biofilm formation and resistance to aminoglycosides. Kozitskaya, S., Cho, S.H., Dietrich, K., Marre, R., Naber, K., Ziebuhr, W. Infect. Immun. (2004) [Pubmed]
  19. Revised interpretation of oxacillin MICs for Staphylococcus epidermidis based on mecA detection. McDonald, C.L., Maher, W.E., Fass, R.J. Antimicrob. Agents Chemother. (1995) [Pubmed]
  20. Killing of oxacillin-exposed staphylococci in human polymorphonuclear leukocytes. Lorian, V., Atkinson, B. Antimicrob. Agents Chemother. (1980) [Pubmed]
  21. Antimicrobial Activities of Daptomycin, Vancomycin, and Oxacillin in Human Monocytes and of Daptomycin in Combination with Gentamicin and/or Rifampin in Human Monocytes and in Broth against Staphylococcus aureus. Baltch, A.L., Ritz, W.J., Bopp, L.H., Michelsen, P.B., Smith, R.P. Antimicrob. Agents Chemother. (2007) [Pubmed]
  22. Efficacy of oxacillin and ampicillin-sulbactam combination in experimental endocarditis caused by beta-lactamase-hyperproducing Staphylococcus aureus. Thauvin-Eliopoulos, C., Rice, L.B., Eliopoulos, G.M., Moellering, R.C. Antimicrob. Agents Chemother. (1990) [Pubmed]
  23. Ocular penetration of subconjunctival oxacillin, methicillin, and cefazolin in rabbits with staphylococcal endophthalmitis. Barza, M., Kane, A., Baum, J. J. Infect. Dis. (1982) [Pubmed]
  24. Unbound and acylated structures of the MecR1 extracellular antibiotic-sensor domain provide insights into the signal-transduction system that triggers methicillin resistance. Marrero, A., Mallorquí-Fernández, G., Guevara, T., García-Castellanos, R., Gomis-Rüth, F.X. J. Mol. Biol. (2006) [Pubmed]
  25. Effect of method of administration on extravascular penetration of four antibiotics. Van Etta, L.L., Kravitz, G.R., Russ, T.E., Fasching, C.E., Gerding, D.N., Peterson, L.R. Antimicrob. Agents Chemother. (1982) [Pubmed]
  26. In vitro activity of linezolid against key gram-positive organisms isolated in the united states: results of the LEADER 2004 surveillance program. Draghi, D.C., Sheehan, D.J., Hogan, P., Sahm, D.F. Antimicrob. Agents Chemother. (2005) [Pubmed]
  27. In vitro evaluation of a novel ketolide antimicrobial agent, RU-64004. Jamjian, C., Biedenbach, D.J., Jones, R.N. Antimicrob. Agents Chemother. (1997) [Pubmed]
  28. OXA-18, a class D clavulanic acid-inhibited extended-spectrum beta-lactamase from Pseudomonas aeruginosa. Philippon, L.N., Naas, T., Bouthors, A.T., Barakett, V., Nordmann, P. Antimicrob. Agents Chemother. (1997) [Pubmed]
  29. The region of the IncN plasmid R46 coding for resistance to beta-lactam antibiotics, streptomycin/spectinomycin and sulphonamides is closely related to antibiotic resistance segments found in IncW plasmids and in Tn21-like transposons. Hall, R.M., Vockler, C. Nucleic Acids Res. (1987) [Pubmed]
  30. Correlation between the resistance genotype determined by multiplex PCR assays and the antibiotic susceptibility patterns of Staphylococcus aureus and Staphylococcus epidermidis. Martineau, F., Picard, F.J., Lansac, N., M¿enard, C., Roy, P.H., Ouellette, M., Bergeron, M.G. Antimicrob. Agents Chemother. (2000) [Pubmed]
  31. OXA-24, a novel class D beta-lactamase with carbapenemase activity in an Acinetobacter baumannii clinical strain. Bou, G., Oliver, A., Martínez-Beltrán, J. Antimicrob. Agents Chemother. (2000) [Pubmed]
  32. Pneumococci stimulate the production of the inducible nitric oxide synthase and nitric oxide by murine macrophages. Orman, K.L., Shenep, J.L., English, B.K. J. Infect. Dis. (1998) [Pubmed]
  33. The VraS/VraR two-component regulatory system required for oxacillin resistance in community-acquired methicillin-resistant Staphylococcus aureus. Boyle-Vavra, S., Yin, S., Daum, R.S. FEMS Microbiol. Lett. (2006) [Pubmed]
  34. Hepatitis from intravenous high-dose oxacillin therapy: findings in an adult inpatient population. Onorato, I.M., Axelrod, J.L. Ann. Intern. Med. (1978) [Pubmed]
  35. A clinico-microbiological study of diabetic foot ulcers in an Indian Tertiary Care Hospital. Gadepalli, R., Dhawan, B., Sreenivas, V., Kapil, A., Ammini, A.C., Chaudhry, R. Diabetes Care (2006) [Pubmed]
  36. Vancomycin-intermediate Staphylococcus aureus in a home health-care patient. Hageman, J.C., Pegues, D.A., Jepson, C., Bell, R.L., Guinan, M., Ward, K.W., Cohen, M.D., Hindler, J.A., Tenover, F.C., McAllister, S.K., Kellum, M.E., Fridkin, S.K. Emerging Infect. Dis. (2001) [Pubmed]
  37. Emerging resistance to antimicrobial agents in gram-positive bacteria. Pneumococci. Appelbaum, P.C. Drugs (1996) [Pubmed]
  38. Oxacillin for bacterial endophthalmitis: subconjunctival, intravenous, both, or neither? Barza, M., Kane, A., Baum, J. Invest. Ophthalmol. Vis. Sci. (1980) [Pubmed]
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