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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Metoclopramide-induced parkinsonism in hemodialysis patients. Report of two cases.

Metoclopramide hydrochloride is an antiemetic and gastric motility stimulant with a wide variety of extrapyramidal side effects, including parkinsonism. We describe two patients with end-stage renal disease secondary to diabetes mellitus treated with hemodialysis who developed extrapyramidal symptoms during treatment with metoclopramide. One patient with preexisting, well-controlled Parkinson's disease developed increasing rigidity and bradykinesia that became completely refractory to treatment with L-dopa and bromocriptine while taking metoclopramide for diabetic gastroparesis. A second patient with no history of Parkinson's disease developed a resting tremor and facial dyskinesia during treatment with metoclopramide. In both cases, discontinuation of metoclopramide therapy led to prompt improvement of symptoms.[1]


  1. Metoclopramide-induced parkinsonism in hemodialysis patients. Report of two cases. Sirota, R.A., Kimmel, P.L., Trichtinger, M.D., Diamond, B.F., Stein, H.D., Yudis, M. Arch. Intern. Med. (1986) [Pubmed]
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