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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Neo-kyotorphin, an analgesic peptide isolated from human lung carcinoma.

A pentapeptide with analgesic activity has been isolated from human lung squamous cell carcinoma and from three other types of propagated tumors of human lung small-cell carcinoma ( SCC), adenoma (AD) and large-cell carcinoma (LCC) in nude mice. The amino acid sequence of the peptide has been revealed to be H-Thr-Ser-Lys-Tyr-Arg-OH, which is exactly the same as that of neo-kyotorphin, an analgesic peptide originally isolated from bovine brain [(1982) Life Sci. 31, 1733]. No neo-kyotorphin could be isolated from normal lung tissue using the same procedures as those used for carcinomas. The results suggest that the presence of neo-kyotorphin in the lung carcinoma may represent the ectopic expression of peptide hormone. Our findings constitute the first example of a human lung carcinoma producing analgesic peptide.[1]

References

  1. Neo-kyotorphin, an analgesic peptide isolated from human lung carcinoma. Zhu, Y.X., Hsi, K.L., Chen, Z.G., Zhang, H.L., Wu, S.X., Zhang, S.Y., Fang, P.F., Guo, S.Y., Kao, Y.S., Tsou, K. FEBS Lett. (1986) [Pubmed]
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