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Bioassay for SF 86-327, a new antifungal agent.

A bioassay with Trichophyton mentagrophytes is described for SF 86-327, an allylamine antifungal agent. SF 86-327 serum concentrations were measured by bioassay in 117 serum sampler from five patients receiving 500 mg/day. The peak, trough, and area under the concentration-time curve were determined after the first dose and at steady state. Drug accumulation occurred with prolonged therapy.[1]

References

  1. Bioassay for SF 86-327, a new antifungal agent. Kan, V.L., Henderson, D.K., Bennett, J.E. Antimicrob. Agents Chemother. (1986) [Pubmed]
 
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