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Chemical Compound Review

ALLYLAMINE     prop-2-en-1-amine

Synonyms: Monoallylamine, Polyallylamine, PAA-L, allyl-amine, PubChem19133, ...
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Disease relevance of ALLYLAMINE


High impact information on ALLYLAMINE

  • This review focuses on the deregulation of gene transcription by redox-activated trans-acting factors after benzo(a)pyrene challenge and the modulation of extracellular matrix signaling in vascular smooth muscle cells by allylamine-induced oxidative injury [6].
  • In this study, we demonstrate that allylamine, a selective cardiovascular toxin in vivo, is actively metabolized in vitro by a purified vascular enzyme (semicarbazide-sensitive amine oxidase), which has been localized recently to vascular smooth muscle cells [7].
  • Oxidative deamination of allylamine to a highly toxic aldehyde, acrolein, was blocked through enzyme inhibition by semicarbazide-sensitive amine oxidase suggests that this vascular enzyme's physiological role may include metabolism of exogenous amines [7].
  • This deduced rat SE sequence is 30.2% identical to the ERG 1 gene, which encodes SE from an allylamine-resistant Saccharomyces cerevisiae mutant [8].
  • Under these same denaturing conditions, 96% of the radioactivity associated with the enzyme remained bound, therefore indicating that allylamine attachment is not to the flavin coenzyme but rather to an active site amino acid residue [9].

Chemical compound and disease context of ALLYLAMINE


Biological context of ALLYLAMINE


Anatomical context of ALLYLAMINE

  • Repeated cycles of allylamine-induced aortic injury in vivo modulate the proliferative potential of smooth muscle cells (SMCs) during serial propagation in vitro [13].
  • In vivo alpha(7)-mRNA and protein expression were enhanced in the aortas of AAM-treated rats [15].
  • Ultrastructural studies were made of the early changes induced in left ventricular myocardium by allylamine given to rats either in drinking water (10.7 mM for 1 to 7 days) or by gavage (100 mg. per kg. per day for 1 or 2 days) [4].
  • Acrolein was detected in homogenates of rat aorta, lung, skeletal muscle, and heart incubated with allylamine [17].
  • The adhesion of mouse STO fibroblast cells was accelerated by the immobilization of polyallylamine [18].

Associations of ALLYLAMINE with other chemical compounds


Gene context of ALLYLAMINE


Analytical, diagnostic and therapeutic context of ALLYLAMINE


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  25. Modulation of cyclin dependent kinase inhibitor proteins and ERK1/2 activity in allylamine-injured vascular smooth muscle cells. Jones, S.A., Patterson, J.L., Chao, J.T., Ramos, K.S., Wilson, E. J. Cell. Biochem. (2004) [Pubmed]
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