The effect of 1-beta-D-arabinofuranosyl-cytosine on the expression of the common fragile site at 3p14.
The effect of the G2-treatment of 1-beta-D-arabino-furanosyl-cytosine (araC) on the expression of the common fragile site at 3p14 (FRA3B) was studied. A significantly increased frequency of FRA3B induced by G2 treatment of araC was found in the lymphocytes grown in folate-deficient medium (positive rate 100%). A relatively low frequency of FRA3B was also induced in the cultures with folate in four of the seven subjects. There is a synergistic effect between araC and growth in folate-deficient medium on the induction of FRA3B. The results suggest that the DNA lesions related to the expression of FRA3B induce the long-patch repair and that the low DNA polymerase alpha activity and inefficient repair process during G2 phase is involved in the expression of FRA3B.[1]References
- The effect of 1-beta-D-arabinofuranosyl-cytosine on the expression of the common fragile site at 3p14. Li, X.Z., Yan, Z.A., Zhou, X.T. Hum. Genet. (1986) [Pubmed]
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