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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Ketanserin and pirenperone attenuate acute morphine withdrawal in rats.

The involvement of serotonin2 (5-HT2) receptors in the expression of opiate withdrawal was examined using a behavioral test for acute morphine dependence. The 5-HT2 antagonists, ketanserin and pirenperone, injected shortly before naloxone, attenuated the naloxone-induced suppression of an autoshaped lever-touch response in rats treated 4 h earlier with a moderate dose of morphine. A low dose of pirenperone was also effective in blocking withdrawal-induced hypothermia. These data support the hypothesis that 5-HT is involved in the expression of opiate withdrawal.[1]


  1. Ketanserin and pirenperone attenuate acute morphine withdrawal in rats. Neal, B.S., Sparber, S.B. Eur. J. Pharmacol. (1986) [Pubmed]
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