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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Analysis of cytogenetic effect in human lymphocytes induced by metabolically activated 2-nitropropane.

Chromosome analyses were carried out in human lymphocytes treated in vitro with 2-nitropropane (2-NP) in the presence and absence of the mammalian metabolic activation system, S9 mix. Without S9 mix, only the frequency of gaps was significantly increased at 80 mM 2-NP as compared to controls. With S9 mix, the incidences of gaps and chromatid-type aberrations were significantly increased at 60 mM and 80 mM. Sister-chromatid exchanges (SCE) have been induced at concentrations as low as 7.5 mM. The present findings demonstrate that in human lymphocytes, 2-NP requires metabolic activation to express clastogenicity and SCEs.[1]

References

  1. Analysis of cytogenetic effect in human lymphocytes induced by metabolically activated 2-nitropropane. Bauchinger, M., Kulka, U., Schmid, E. Mutat. Res. (1987) [Pubmed]
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