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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Assignment of Lap-1 to linkage group I of the rat (Rattus norvegicus).

Genetic analysis of backcross progeny from previously characterized rat inbred strains revealed that the biochemical marker Lap-1 is localized in linkage group I (LG I). Lap-1 codes for leucine arylaminopeptidase (EC 3.4.11). The distances of Lap-1 to c, RT6, and Hbb, based on recombination frequencies, are 3.1 +/- 1.5, 8.3 +/- 4.0, and 11.4 +/- 2.8 cM, respectively. Acon-1 codes for aconitase (EC 4.2.1.3). The calculated distances of Acon-1 to c and Hbb are 30.1 +/- 5.0 and 36.1 +/- 5.3 cM, respectively. This suggests that Acon-1 is also in LG I, but the observed high frequency of double crossovers requires further confirmation of this linkage. Ahd-2, Es-6, and Gdc-1 are linked neither to markers of LG I nor to one another.[1]

References

  1. Assignment of Lap-1 to linkage group I of the rat (Rattus norvegicus). van Zutphen, L.F., den Bieman, M., Hedrich, H.J., Kluge, R. Biochem. Genet. (1985) [Pubmed]
 
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