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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Rats, Inbred Strains

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Disease relevance of Rats, Inbred Strains


Psychiatry related information on Rats, Inbred Strains


High impact information on Rats, Inbred Strains


Chemical compound and disease context of Rats, Inbred Strains


Biological context of Rats, Inbred Strains


Anatomical context of Rats, Inbred Strains


Associations of Rats, Inbred Strains with chemical compounds


Gene context of Rats, Inbred Strains

  • We identified polymorphisms in H19 and Igf2 transcripts in two inbred rat strains and determined the expression of the parental alleles in F1 offspring [32].
  • The two inbred rat strains did not differ in hepatic microsomal phenacetin deethylase activity, which is a marker for CYP1A2 activity important for the activation of aromatic amines [33].
  • An intronless Fabp6 segment was found in four related rat inbred strains (SHR; SHRSP; WKY; and OKA), but not in 62 other rat inbred strains [34].
  • The goals of the present study were (i) to define the neuronal pattern of immunoreactive Fos expression to the airpuff stimulus, and (ii) to determine whether this pattern of expression differed between the two contrasting inbred rat strains, thereby relating to observed differences in response [35].
  • Hsc70-specific probes detect a large number of more than 20 cross-hybridizing fragments, which show only limited length polymorphism among various inbred rat strains [36].

Analytical, diagnostic and therapeutic context of Rats, Inbred Strains


  1. Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology. Storch, M.K., Stefferl, A., Brehm, U., Weissert, R., Wallström, E., Kerschensteiner, M., Olsson, T., Linington, C., Lassmann, H. Brain Pathol. (1998) [Pubmed]
  2. Resistance to experimental autoimmune myasthenia gravis in genetically inbred rats. Association with decreased amounts of in situ acetylcholine receptor-antibody complexes. Biesecker, G., Koffler, D. J. Immunol. (1988) [Pubmed]
  3. Ibudilast, a phosphodiesterase inhibitor, ameliorates experimental autoimmune encephalomyelitis in Dark August rats. Fujimoto, T., Sakoda, S., Fujimura, H., Yanagihara, T. J. Neuroimmunol. (1999) [Pubmed]
  4. Influence of thiamine deficiency on the response to ethanol in two inbred rat strains. Impeduglia, G., Martin, P.R., Kwast, M., Hohlstein, L.A., Roehrich, L., Majchrowicz, E. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  5. An inbred strain of rats with a high incidence of squamous-cell carcinomas of the mouth. Buckley, P., Hulse, E.V., Keep, B.M. Br. J. Cancer (1980) [Pubmed]
  6. Effects of cocaine on locomotor activity and schedule-controlled behaviors of inbred rat strains. Witkin, J.M., Goldberg, S.R. Pharmacol. Biochem. Behav. (1990) [Pubmed]
  7. Effects of periadolescent ethanol exposure on alcohol preference in two BALB substrains. Blizard, D.A., Vandenbergh, D.J., Jefferson, A.L., Chatlos, C.D., Vogler, G.P., McClearn, G.E. Alcohol (2004) [Pubmed]
  8. Spontaneous thymoma in an inbred strain of rat. Hinsull, S.M., Bellamy, D. J. Natl. Cancer Inst. (1977) [Pubmed]
  9. Delayed erythropoiesis in irradiated rats grafted with syngeneic marrow: effects of cytotoxic drugs and iron-deficiency anemia. Rodday, P., Bennett, M., Vitale, J.J. Blood (1976) [Pubmed]
  10. Physical map and expression profile of genes of the telomeric class I gene region of the rat MHC. Ioannidu, S., Walter, L., Dressel, R., Günther, E. J. Immunol. (2001) [Pubmed]
  11. The glycosylation of rat intestinal Muc2 mucin varies between rat strains and the small and large intestine. A study of O-linked oligosaccharides by a mass spectrometric approach. Karlsson, N.G., Herrmann, A., Karlsson, H., Johansson, M.E., Carlstedt, I., Hansson, G.C. J. Biol. Chem. (1997) [Pubmed]
  12. Susceptibility and resistance to 6-sulfanilamidoindazole-induced arthritis among inbred strains of rats. Samuelson, C.O., Griffiths, M.M., Mathews, J.L., Clegg, D.O., Ward, J.R. Arthritis Rheum. (1984) [Pubmed]
  13. Regional differences in brain norepinephrine and dopamine uptake kinetics in inbred rat strains with hypertension and/or hyperactivity. Hendley, E.D., Fan, X.M. Brain Res. (1992) [Pubmed]
  14. Experimental diabetic renal growth: role of growth hormone and insulin-like growth factor-I. Muchaneta-Kubara, E.C., Sayed-Ahmed, N., Besbas, N., Zhang, G., Cope, G.H., el Nahas, A.M. Nephrol. Dial. Transplant. (1994) [Pubmed]
  15. Sustained nicotine release comparisons in six inbred rat strains. Erickson, C.K., Byers, K.I. Pharmacol. Biochem. Behav. (1989) [Pubmed]
  16. Quantitative trait loci determining weight reduction of testes and pituitary by diethylstilbesterol in LEXF and FXLE recombinant inbred strain rats. Tachibana, M., Lu, L., Hiai, H., Tamura, A., Matsushima, Y., Shisa, H. Exp. Anim. (2006) [Pubmed]
  17. Arcuate NPY neurons and energy homeostasis in diet-induced obese and resistant rats. Levin, B.E. Am. J. Physiol. (1999) [Pubmed]
  18. Seven renin alleles in rats and their effects on blood pressure. Rapp, J.P., Dene, H., Deng, A.Y. J. Hypertens. (1994) [Pubmed]
  19. Characteristics of the aortic elastic network and related phenotypes in seven inbred rat strains. Behmoaras, J., Osborne-Pellegrin, M., Gauguier, D., Jacob, M.P. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  20. Genetic maps of polymorphic DNA loci on rat chromosome 1. Ding, Y.P., Remmers, E.F., Du, Y., Longman, R.E., Goldmuntz, E.A., Zha, H., Kotake, S., Cannon, G.W., Griffiths, M.M., Wilder, R.L. Genomics (1996) [Pubmed]
  21. Genomic organization of the rat Clock gene and sequence analysis in inbred rat strains. Woon, P.Y., Curtis, A.M., Kaisaki, P.J., Argoud, K., Wallace, K.J., Bihoreau, M.T., FitzGerald, G.A., Gauguier, D. Genomics (2006) [Pubmed]
  22. Complementary DNA sequences encoding the rat MHC class II RT1-Bu and RT1-Du alpha and beta chains. Easterfield, A.J., Bradley, J.A., Bolton, E.M. Immunogenetics (2003) [Pubmed]
  23. The influence of methimazole on thyroglobulin-induced autoimmune thyroiditis in the rat. Rennie, D.P., McGregor, A.M., Keast, D., Weetman, A.P., Foord, S.M., Dieguez, C., Williams, E.D., Hall, R. Endocrinology (1983) [Pubmed]
  24. Do infectious agents cause rheumatoid arthritis? Wilder, R.L., Crofford, L.J. Clin. Orthop. Relat. Res. (1991) [Pubmed]
  25. Failure of acetylcholine to release histamine from rat mast cells. Kazimierczak, W., Adamas, B., Maśliński, C. Agents Actions (1980) [Pubmed]
  26. Differences in the response of superior cervical ganglion dopamine-beta-hydroxylase activity to immobilization stress between inbred rat strains. Cooper, D.O., Stolk, J.M. Communications in psychopharmacology. (1977) [Pubmed]
  27. Effect of voluntary exercise on H2O2 release by subsarcolemmal and intermyofibrillar mitochondria. Servais, S., Couturier, K., Koubi, H., Rouanet, J.L., Desplanches, D., Sornay-Mayet, M.H., Sempore, B., Lavoie, J.M., Favier, R. Free Radic. Biol. Med. (2003) [Pubmed]
  28. FK506--its influence on anti-class 1 MHC alloantibody responses to blood transfusions. Propper, D.J., Woo, J., Thomson, A.W., Catto, G.R., Macleod, A.M. Transplantation (1990) [Pubmed]
  29. Strain-dependent differences in oxygen-induced retinopathy in the inbred rat. van Wijngaarden, P., Coster, D.J., Brereton, H.M., Gibbins, I.L., Williams, K.A. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  30. Differential responses of two inbred rat strains to a choline-deficient diet during liver carcinogenesis. Hinrichsen, L.I., Sudilovsky, E.C., Roggero, E., Jiang, S.H., Sudilovsky, O. Carcinogenesis (1993) [Pubmed]
  31. The fibrinolytic system in experimental prostate tumor. Al-Mondhiry, H., Drago, J., Bartholomew, M.J. Thromb. Haemost. (1986) [Pubmed]
  32. Genomic imprinting in the rat: linkage of Igf2 and H19 genes and opposite parental allele-specific expression during embryogenesis. Overall, M., Bakker, M., Spencer, J., Parker, N., Smith, P., Dziadek, M. Genomics (1997) [Pubmed]
  33. Higher frequency of aberrant crypt foci in rapid than slow acetylator inbred rats administered the colon carcinogen 3,2'-dimethyl-4-aminobiphenyl. Feng, Y., Fretland, A.J., Rustan, T.D., Jiang, W., Becker, W.K., Hein, D.W. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  34. Sequencing and chromosomal localization of Fabp6 and an intronless Fabp6 segment in the rat. Bonné, A., Gösele, C., den Bieman, M., Gillissen, G., Kreitler, T., Pravenec, M., Kren, V., van Lith, H., van Zutphen, B. Mol. Biol. Rep. (2003) [Pubmed]
  35. Strain differences in Fos expression following airpuff startle in Spontaneously Hypertensive and Wistar Kyoto rats. Palmer, A.A., Printz, M.P. Neuroscience (1999) [Pubmed]
  36. Characterization and mapping of a highly conserved processed pseudogene and an intron-carrying gene of the heat shock cognate protein 70 (Hsc70) gene family in the rat. Rothermel, E., Detzler, E., Walter, L., Levan, G., Günther, E. Mamm. Genome (1995) [Pubmed]
  37. Vein replacement with fresh vital veins: a comparison of transplantation in RT-1-different rat strain combinations. Thiede, A., Engemann, R., Korner, H.H., Deltz, E., Muller-Ruchholtz, W. Ann. Surg. (1981) [Pubmed]
  38. Variations in cocaine self-administration by inbred rat strains under a progressive-ratio schedule. Ward, A.S., Li, D.H., Luedtke, R.R., Emmett-Oglesby, M.W. Psychopharmacology (Berl.) (1996) [Pubmed]
  39. Structural variants of the alpha-fetoprotein gene in different inbred strains of rat. Gal, A., Nahon, J.L., Lucotte, G., Sala-Trepat, J.M. Mol. Gen. Genet. (1984) [Pubmed]
  40. Limb allografts in rats immunosuppressed with cyclosporine: as a whole-joint allograft. Hotokebuchi, T., Arai, K., Takagishi, K., Arita, C., Sugioka, Y., Kaibara, N. Plast. Reconstr. Surg. (1989) [Pubmed]
  41. Ex vivo propagation and characterization of lymphocytes from rejecting rat-kidney allografts. Engstrand, M., Johnsson, C., Korsgren, O., Tufveson, G. Transpl. Immunol. (1999) [Pubmed]
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