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Gene Review

Anpep  -  alanyl (membrane) aminopeptidase

Rattus norvegicus

Synonyms: AP-M, AP-N, Alanyl aminopeptidase, Aminopeptidase M, Aminopeptidase N, ...
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Disease relevance of Anpep


Psychiatry related information on Anpep


High impact information on Anpep


Chemical compound and disease context of Anpep

  • DMSO significantly enhanced the effect of beta APN in reducing the cross-linking of collagen. beta APN administered onto urea-pretreated skin and followed by occlusion in the granuloma tissue was more effective than beta APN in 30% DMSO, but only in the parameter reflecting extractibility of collagen into urea or thiocyanate solutions [3].
  • Pre-incubation of rat PTCs with either acivicin, an inhibitor of gamma-glutamyl transpeptidase (gamma-GT), or bestatin, an inhibitor of aminopeptidase M, resulted in increased toxicity of 5-(glutathion- S-yl)-alpha-MeDA but had no effect on 2,5- bis(glutathion- S-yl)-alpha-MeDA-mediated cytotoxicity [12].
  • In the present study we describe changes in aorta at the protein level associated with allylamine (AA) and beta-aminopropionitrile (beta APN) induced vascular toxicity in a rat model [13].
  • We conclude that topically administered beta APN fumarate onto the intact skin penetrates the stratum corneum and effectively inhibits collagen crosslinking in the underlying granuloma tissue [14].
  • Administration of beta-aminopropionitrile (beta APN) fumarate on the intact skin overlying the implanted PVA sponge in the presence and absence of dimethyl sulfoxide (DMSO) during the growth phase of granuloma development (4th through 12th days after implantation) was accompanied by significant inhibition of collagen polymerization [14].

Biological context of Anpep


Anatomical context of Anpep


Associations of Anpep with chemical compounds


Physical interactions of Anpep

  • Enkephalinase was localized by using a coupled enzyme assay based upon the sequential cleavage of the synthetic peptide substrate glutaryl-ala-ala-phe-4-methoxy-2-naphthylamide by enkephalinase and exogenous aminopeptidase M. Enzyme distribution was examined in segments from cervical, thoracic, lumbar, and sacral cord [23].
  • Approximately 60% of the dipeptidyl peptidase IV interacted with either one or both of the lectins while only 30% of the aminopeptidase N did so [24].

Other interactions of Anpep


Analytical, diagnostic and therapeutic context of Anpep


  1. Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: a member of a super family of zinc-metallohydrolases. Malfroy, B., Kado-Fong, H., Gros, C., Giros, B., Schwartz, J.C., Hellmiss, R. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  2. The effects of beta-aminopropionitrile on the growing rat lung. Kida, K., Thurlbeck, W.M. Am. J. Pathol. (1980) [Pubmed]
  3. Effect of topically applied beta-aminopropionitrile on granuloma tissue biochemistry. Lata, A., Gowri, C., Dhar, S.C., Gibeault, J.D., Chvapil, M. Proc. Soc. Exp. Biol. Med. (1988) [Pubmed]
  4. Changes in the expression pattern of blood-brain barrier-associated pericytic aminopeptidase N (pAP N) in the course of acute experimental autoimmune encephalomyelitis. Kunz, J., Krause, D., Gehrmann, J., Dermietzel, R. J. Neuroimmunol. (1995) [Pubmed]
  5. Ontogenic and adult whole body distribution of aminopeptidase N in rat investigated by in vitro autoradiography. Jardinaud, F., Banisadr, G., Noble, F., Mélik-Parsadaniantz, S., Chen, H., Dugave, C., Laplace, H., Rostène, W., Fournié-Zaluski, M.C., Roques, B.P., Popovici, T. Biochimie (2004) [Pubmed]
  6. Effects of morphine administration and its withdrawal on rat brain aminopeptidase activities. Irazusta, J., Larrinaga, G., Agirregoitia, N., Varona, A., Casis, L. Regul. Pept. (2003) [Pubmed]
  7. Dietary aspartame with protein on plasma and brain amino acids, brain monoamines and behavior in rats. Torii, K., Mimura, T., Takasaki, Y., Ichimura, M. Physiol. Behav. (1986) [Pubmed]
  8. Evidence for the role of angiotensin II biosynthesis in the rat internal anal sphincter tone. De Godoy, M.A., Dunn, S., Rattan, S. Gastroenterology (2004) [Pubmed]
  9. Cdx1 promotes differentiation in a rat intestinal epithelial cell line. Soubeyran, P., André, F., Lissitzky, J.C., Mallo, G.V., Moucadel, V., Roccabianca, M., Rechreche, H., Marvaldi, J., Dikic, I., Dagorn, J.C., Iovanna, J.L. Gastroenterology (1999) [Pubmed]
  10. Newly synthesized hepatocyte plasma membrane proteins are transported in transcytotic vesicles in the bile duct-ligated rat. Barr, V.A., Hubbard, A.L. Gastroenterology (1993) [Pubmed]
  11. Immunochemical localization of aminopeptidase M in the alimentary tract of the guinea pig and rat. Terashima, H., Wong, H., Kobayashi, R., Bunnett, N.W. Gastroenterology (1992) [Pubmed]
  12. Role of metabolites in MDMA (ecstasy)-induced nephrotoxicity: an in vitro study using rat and human renal proximal tubular cells. Carvalho, M., Hawksworth, G., Milhazes, N., Borges, F., Monks, T.J., Fernandes, E., Carvalho, F., Bastos, M.L. Arch. Toxicol. (2002) [Pubmed]
  13. Allylamine and beta-aminopropionitrile-induced vascular injury: enhanced expression of high-molecular-weight proteins. Awasthi, S., Boor, P.J. J. Toxicol. Environ. Health Part A (1998) [Pubmed]
  14. Topical beta-aminopropionitrile and biochemistry of granuloma tissue. Lata, A., Gowri, C., Dhar, S.C., Chvapil, M. J. Surg. Res. (1988) [Pubmed]
  15. Amino acid sequence deduced from a rat kidney cDNA suggests it encodes the Zn-peptidase aminopeptidase N. Watt, V.M., Yip, C.C. J. Biol. Chem. (1989) [Pubmed]
  16. The major APN transcript of the alveolar type II epithelial cell originates from a unique upstream promoter region. Gillis, L.D., Pendley, D.S., Funkhouser, J.D. Biochim. Biophys. Acta (1998) [Pubmed]
  17. Identification and characterization of brush-border membrane-bound neutral metalloendopeptidases from rat small intestine. Song, I.S., Yoshioka, M., Erickson, R.H., Miura, S., Guan, D., Kim, Y.S. Gastroenterology (1986) [Pubmed]
  18. First discrete autoradiographic distribution of aminopeptidase N in various structures of rat brain and spinal cord using the selective iodinated inhibitor [125I]RB 129. Noble, F., Banisadr, G., Jardinaud, F., Popovici, T., Lai-Kuen, R., Chen, H., Bischoff, L., Parsadaniantz, S.M., Fournie-Zaluski, M.C., Roques, B.P. Neuroscience (2001) [Pubmed]
  19. Evidence for apical endocytosis in polarized hepatic cells: phosphoinositide 3-kinase inhibitors lead to the lysosomal accumulation of resident apical plasma membrane proteins. Tuma, P.L., Finnegan, C.M., Yi, J.H., Hubbard, A.L. J. Cell Biol. (1999) [Pubmed]
  20. Histochemical visualization of neutral endopeptidase-24.11 (enkephalinase) activity in rat brain: cellular localization and codistribution with enkephalins in the globus pallidus. Back, S.A., Gorenstein, C. J. Neurosci. (1989) [Pubmed]
  21. The effect of beta-aminopropionitrile on lung development in the rat. Das, R.M. Am. J. Pathol. (1980) [Pubmed]
  22. The major protein of GLUT4-containing vesicles, gp160, has aminopeptidase activity. Kandror, K.V., Yu, L., Pilch, P.F. J. Biol. Chem. (1994) [Pubmed]
  23. Fluorescent histochemical localization of neutral endopeptidase-24.11 (enkephalinase) in the rat spinal cord. Back, S.A., Gorenstein, C. J. Comp. Neurol. (1989) [Pubmed]
  24. Interaction of purified brush-border membrane aminopeptidase N and dipeptidyl peptidase IV with lectin-sepharose derivatives. Erickson, R.H., Kim, Y.S. Biochim. Biophys. Acta (1983) [Pubmed]
  25. Biogenesis of the rat hepatocyte plasma membrane in vivo: comparison of the pathways taken by apical and basolateral proteins using subcellular fractionation. Bartles, J.R., Feracci, H.M., Stieger, B., Hubbard, A.L. J. Cell Biol. (1987) [Pubmed]
  26. Rat liver canalicular membrane vesicles. Isolation and topological characterization. Inoue, M., Kinne, R., Tran, T., Biempica, L., Arias, I.M. J. Biol. Chem. (1983) [Pubmed]
  27. Cytotoxicity of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine in isolated rat kidney cells. Lash, L.H., Anders, M.W. J. Biol. Chem. (1986) [Pubmed]
  28. Does neomucosa induced by small bowel stem cell transplantation have adequate function? Tait, I.S., Penny, J.I., Campbell, F.C. Am. J. Surg. (1995) [Pubmed]
  29. Myosin in cultured vascular smooth muscle cells: immunofluorescence and immunochemical studies of alterations in antigenic expression. Larson, D.M., Fujiwara, K., Alexander, R.W., Gimbrone, M.A. J. Cell Biol. (1984) [Pubmed]
  30. Homology modeling and site-directed mutagenesis of pyroglutamyl peptidase II. Insights into omega-versus aminopeptidase specificity in the M1 family. Chávez-Gutiérrez, L., Matta-Camacho, E., Osuna, J., Horjales, E., Joseph-Bravo, P., Maigret, B., Charli, J.L. J. Biol. Chem. (2006) [Pubmed]
  31. Regulation of a blood-brain barrier-specific enzyme expressed by cerebral pericytes (pericytic aminopeptidase N/pAPN) under cell culture conditions. Ramsauer, M., Kunz, J., Krause, D., Dermietzel, R. J. Cereb. Blood Flow Metab. (1998) [Pubmed]
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