The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

In vitro activity of temocillin against gram-negative clinical isolates.

120 consecutive clinical isolates of various species of Enterobacteriaceae and 30 consecutive clinical isolates of Haemophilus influenzae (including 5 which produced beta-lactamase) were assessed for susceptibility to temocillin using a broth microdilution technique and both 'light' (10(3) CFU/ml) and 'heavy' (10(6) CFU/ml) inocula. At the lighter inoculum, 90% of the Enterobacteriaceae were inhibited by temocillin at a concentration of 4 mg/L. 90% of the H. influenzae were similarly inhibited at a concentration of 0.5 mg/L, and no differences were observed between producers and non-producers of beta-lactamase. At the heavier inoculum, a significant inoculum effect was observed: minimum inhibitory concentrations (MICs) increased up to 128-fold for H. influenzae and somewhat less than that for the Enterobacteriaceae. Klebsiella pneumoniae was least affected by inoculum, showing only a 2- to 4-fold increase in the MIC. It is concluded that temocillin is active in vitro against the species tested and warrants further clinical trial.[1]


  1. In vitro activity of temocillin against gram-negative clinical isolates. Gaya, H., Hutchinson, G.R., Chadwick, M.V. Drugs (1985) [Pubmed]
WikiGenes - Universities