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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Beta-lactamase stability of temocillin.

The stability of temocillin to 12 different beta-lactamase preparations was studied using high pressure liquid chromatography and was compared with that of aztreonam, cefotetan and cefotaxime. Temocillin was the most stable beta-lactam examined, being as stable as cefotetan to most of the beta-lactamases tested. However, cefotetan was hydrolysed at measurable rates by the beta-lactamase of Enterobacter cloacae P99, in contrast to temocillin which was completely stable to this enzyme. Aztreonam was hydrolysed at a slow rate by many of the preparations, being especially labile to the enzyme from Klebsiella oxytoca K1. Cefotaxime was hydrolysed at varying rates by all the preparations.[1]


  1. Beta-lactamase stability of temocillin. Edmondson, R.A., Reading, C. Drugs (1985) [Pubmed]
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