- Hemoglobin Rahere, a human hemoglobin variant with amino acid substitution at the 2,3-diphosphoglycerate binding site. Functional consequences of the alteration and effects of bezafibrate on the oxygen bindings. Sugihara, J., Imamura, T., Nagafuchi, S., Bonaventura, J., Bonaventura, C., Cashon, R. J. Clin. Invest. (1985)