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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cardiolipin is the membrane receptor for mitochondrial creatine phosphokinase.

Treatment of rat heart mitochondria with phosphate or mersalyl releases a number of proteins, including the mitochondrial creatine kinase (mt-CK). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the released proteins showed that phosphate is more selective than mersalyl in releasing mt-CK. The rebinding of mt-CK to mitochondria was selectively inhibited by adriamycin, which complexes membrane-bound cardiolipin. mt-CK activity and binding experiments have shown that intact mitochondria are able to bind approximately twice the amount of mt-CK they originally contain. Liver mitochondria bound heart mitochondria mt-CK to the same extent as creatine kinase-depleted heart mitochondria. mt-CK was bound by liposomes but only if they contained cardiolipin. The binding of mt-CK to cardiolipin-containing liposomes was inhibited by adriamycin. Phosphatidylcholine liposomes reconstituted with the purified ADP/ATP translocator failed to bind mt-CK.[1]


  1. Cardiolipin is the membrane receptor for mitochondrial creatine phosphokinase. Müller, M., Moser, R., Cheneval, D., Carafoli, E. J. Biol. Chem. (1985) [Pubmed]
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