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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Are plasma lipoprotein cholesteryl esters utilized for biliary cholesterol and bile acid production in man?

Studies were carried out to determine whether or not plasma lipoprotein cholesteryl esters are available to the liver for biliary cholesterol and bile acid production in humans with intact biliary tracts. Six healthy males were given intravenous infusions of autologous high-density (d, 1.063-1.21; n = 2), low-density (d, 1.019-1.063; n = 2) or intermediate-density (d, 1.006-1.019; n = 2) lipoproteins that had been labelled in vitro with radioactive cholesteryl linoleate (n = 5) or cholesteryl oleate (n = 1). Duodenal contents were continuously aspirated via the intermediate and distal ports of a triple-lumen tube (mean recovery, 64 per cent), through the proximal port of which was infused an amino-acid solution. During 5-6 hours only moderate fluctuations were observed in bile acid and cholesterol secretion rates, implying the existence of near steady-state conditions. In all subjects radioactivity rapidly appeared in both biliary cholesterol and bile acids, and continued to be secreted for the duration of the experiment. The total radioactivity recovered from cholesterol averaged 0.27 per cent of the administered dose; the corresponding figure for bile acids was 11.2 per cent. These results indicate that lipoprotein cholesteryl esters are readily available for biliary lipid production in humans.[1]


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