The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effect of hydration on experimentally induced cerebral edema.

Although fluid restriction is often used to manage cerebral edema, there have been no controlled studies which demonstrate its benefit. We evaluated the effects of dehydration and overhydration on the development of cerebral edema in rats subjected to triethyltin poisoning or anoxic ischemia. Four days after triethyltin poisoning, the brains of control rats receiving maintenance hydration had a mean percentage of water of 79.56%; dehydration (5% of body weight) and overhydration groups were not statistically different at 79.95% and 79.86%, respectively. Forty-seven hours after an anoxic-ischemic insult consisting of unilateral carotid artery ligation and subsequent exposure to a 4% oxygen atmosphere for 30 min, the percentage of water in control rats was 79.12%; dehydration (13% of body weight) and overhydration groups were 79.10% and 79.16%, respectively. Histopathologic analysis of brain sections did not differentiate the hydration groups (triethyltin model only). Thus, cerebral edema was not altered by hydration status in either poisoned or ischemic animals.[1]


  1. Effect of hydration on experimentally induced cerebral edema. Morse, M.L., Milstein, J.M., Haas, J.E., Taylor, E. Crit. Care Med. (1985) [Pubmed]
WikiGenes - Universities