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MeSH Review

Brain Edema

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Disease relevance of Brain Edema


Psychiatry related information on Brain Edema


High impact information on Brain Edema

  • A comparison of the children with cerebral edema with those in the matched control group also showed that cerebral edema was associated with lower partial pressures of arterial carbon dioxide and higher serum urea nitrogen concentrations [1].
  • CTLN2 patients (1/100,000 in Japan) suffer from a disturbance of consciousness and coma, and most die with cerebral edema within a few years of onset [8].
  • In spite of this response, one subject had mild cerebral edema on brain CT after both placebo and dexamethasone [9].
  • These results implicate a key role for AQP4 in modulating brain water transport, and suggest that AQP4 inhibition may provide a new therapeutic option for reducing brain edema in a wide variety of cerebral disorders [2].
  • Islet-infiltrating T (IIT) cells from two IDDM patients, who had died at the onset of the disease from brain swelling as a complication of ketoacidosis, were analysed [10].

Chemical compound and disease context of Brain Edema


Biological context of Brain Edema


Anatomical context of Brain Edema


Gene context of Brain Edema

  • Consequently, it is of paramount importance to ascertain the phenotypic nature of AQP4 mRNA-expressing cells in the CNS before attempting future clinical studies aimed at minimizing the development of brain edema [25].
  • Glioblastoma cells are most malignant and show resistance to radiation therapy inducing VEGF to cause angiogenesis and brain edema [26].
  • Present results obtained indicate that it is possible to reduce or prevent the late effects of SAH, i.e., neuronal hypoxia and cerebral edema, through the inhibition of endothelin-1 induced vasospasm [27].
  • In the brain, deletion of AQP4 conferred marked protection from brain swelling induced by acute water intoxication and ischaemic stroke [28].
  • There have been recent reports describing different aquaporin-responses under pathologic states leading to brain edema [29].

Analytical, diagnostic and therapeutic context of Brain Edema


  1. Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. Glaser, N., Barnett, P., McCaslin, I., Nelson, D., Trainor, J., Louie, J., Kaufman, F., Quayle, K., Roback, M., Malley, R., Kuppermann, N. N. Engl. J. Med. (2001) [Pubmed]
  2. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Manley, G.T., Fujimura, M., Ma, T., Noshita, N., Filiz, F., Bollen, A.W., Chan, P., Verkman, A.S. Nat. Med. (2000) [Pubmed]
  3. Convulsions complicating colectomy in inflammatory bowel disease. Schulak, J.A., Moossa, R., Block, G.E., Kirsner, J.B. JAMA (1977) [Pubmed]
  4. Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains. Patt, A., Harken, A.H., Burton, L.K., Rodell, T.C., Piermattei, D., Schorr, W.J., Parker, N.B., Berger, E.M., Horesh, I.R., Terada, L.S. J. Clin. Invest. (1988) [Pubmed]
  5. Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms. Berkman, R.A., Merrill, M.J., Reinhold, W.C., Monacci, W.T., Saxena, A., Clark, W.C., Robertson, J.T., Ali, I.U., Oldfield, E.H. J. Clin. Invest. (1993) [Pubmed]
  6. Pain threshold, learning and formation of brain edema in mice lacking the angiotensin II type 2 receptor. Sakagawa, T., Okuyama, S., Kawashima, N., Hozumi, S., Nakagawasai, O., Tadano, T., Kisara, K., Ichiki, T., Inagami, T. Life Sci. (2000) [Pubmed]
  7. Hyperammonemia, bane of the brain. Cohn, R.M., Roth, K.S. Clinical pediatrics. (2004) [Pubmed]
  8. The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein. Kobayashi, K., Sinasac, D.S., Iijima, M., Boright, A.P., Begum, L., Lee, J.R., Yasuda, T., Ikeda, S., Hirano, R., Terazono, H., Crackower, M.A., Kondo, I., Tsui, L.C., Scherer, S.W., Saheki, T. Nat. Genet. (1999) [Pubmed]
  9. Dexamethasone in the treatment of acute mountain sickness. Levine, B.D., Yoshimura, K., Kobayashi, T., Fukushima, M., Shibamoto, T., Ueda, G. N. Engl. J. Med. (1989) [Pubmed]
  10. Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology. Conrad, B., Weidmann, E., Trucco, G., Rudert, W.A., Behboo, R., Ricordi, C., Rodriquez-Rilo, H., Finegold, D., Trucco, M. Nature (1994) [Pubmed]
  11. Duration of vidarabine therapy in biopsy-negative herpes simplex encephalitis. Landry, M.L., Booss, J., Hsiung, G.D. JAMA (1982) [Pubmed]
  12. Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study. Chatauret, N., Zwingmann, C., Rose, C., Leibfritz, D., Butterworth, R.F. Gastroenterology (2003) [Pubmed]
  13. Mild hypothermia modifies ammonia-induced brain edema in rats after portacaval anastomosis. Córdoba, J., Crespin, J., Gottstein, J., Blei, A.T. Gastroenterology (1999) [Pubmed]
  14. Delayed onset of brain edema and mislocalization of aquaporin-4 in dystrophin-null transgenic mice. Vajda, Z., Pedersen, M., Füchtbauer, E.M., Wertz, K., Stødkilde-Jørgensen, H., Sulyok, E., Dóczi, T., Neely, J.D., Agre, P., Frøkiaer, J., Nielsen, S. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  15. Pharmacological basis for the use of nimodipine in central nervous system disorders. Scriabine, A., Schuurman, T., Traber, J. FASEB J. (1989) [Pubmed]
  16. Fulminant hepatitis in a tropical population: clinical course, cause, and early predictors of outcome. Acharya, S.K., Dasarathy, S., Kumer, T.L., Sushma, S., Prasanna, K.S., Tandon, A., Sreenivas, V., Nijhawan, S., Panda, S.K., Nanda, S.K., Irshad, M., Joshi, Y.K., Duttagupta, S., Tandon, R.K., Tandon, B.N. Hepatology (1996) [Pubmed]
  17. Regional blood flow in compression-induced brain edema in rats: effect of dietary vitamin E. Busto, R., Yoshida, S., Ginsberg, M.D., Alonso, O., Smith, D.W., Goldberg, W.J. Ann. Neurol. (1984) [Pubmed]
  18. Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis. Papadopoulos, M.C., Verkman, A.S. J. Biol. Chem. (2005) [Pubmed]
  19. Correlates of brain edema in uncontrolled IDDM. Durr, J.A., Hoffman, W.H., Sklar, A.H., el Gammal, T., Steinhart, C.M. Diabetes (1992) [Pubmed]
  20. Brain edema and intracranial hypertension in rats after total hepatectomy. Olafsson, S., Gottstein, J., Blei, A.T. Gastroenterology (1995) [Pubmed]
  21. Neurobiology of ammonia. Felipo, V., Butterworth, R.F. Prog. Neurobiol. (2002) [Pubmed]
  22. Effect of dexamethasone on blood-brain barrier in the normal mouse. Hedley-Whyte, E.T., Hsu, D.W. Ann. Neurol. (1986) [Pubmed]
  23. L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure. Rose, C., Michalak, A., Rao, K.V., Quack, G., Kircheis, G., Butterworth, R.F. Hepatology (1999) [Pubmed]
  24. The maxi-K channel opener BMS-204352 attenuates regional cerebral edema and neurologic motor impairment after experimental brain injury. Cheney, J.A., Weisser, J.D., Bareyre, F.M., Laurer, H.L., Saatman, K.E., Raghupathi, R., Gribkoff, V., Starrett , J.E., McIntosh, T.K. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  25. In vivo expression of aquaporin-4 by reactive microglia. Tomás-Camardiel, M., Venero, J.L., de Pablos, R.M., Rite, I., Machado, A., Cano, J. J. Neurochem. (2004) [Pubmed]
  26. Mitogen-activated protein kinase, ERK1/2, is essential for the induction of vascular endothelial growth factor by ionizing radiation mediated by activator protein-1 in human glioblastoma cells. Mori, K., Tani, M., Kamata, K., Kawamura, H., Urata, Y., Goto, S., Kuwano, M., Shibata, S., Kondo, T. Free Radic. Res. (2000) [Pubmed]
  27. Cerebral angiogenesis and expression of VEGF after subarachnoid hemorrhage (SAH) in rats. Jośko, J. Brain Res. (2003) [Pubmed]
  28. Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice. Verkman, A.S., Yang, B., Song, Y., Manley, G.T., Ma, T. Exp. Physiol. (2000) [Pubmed]
  29. Aquaporin water channels in central nervous system. Lehmann, G.L., Gradilone, S.A., Marinelli, R.A. Current neurovascular research. (2004) [Pubmed]
  30. Induction of brain edema following intracerebral injection of arachidonic acid. Chan, P.H., Fishman, R.A., Caronna, J., Schmidley, J.W., Prioleau, G., Lee, J. Ann. Neurol. (1983) [Pubmed]
  31. Treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm with tranexamic acid: a double-blind clinical trial. Chandra, B. Ann. Neurol. (1978) [Pubmed]
  32. Ammonia-induced brain edema and intracranial hypertension in rats after portacaval anastomosis. Blei, A.T., Olafsson, S., Therrien, G., Butterworth, R.F. Hepatology (1994) [Pubmed]
  33. Survival with full neurologic recovery and no cerebral pathology after prolonged cardiopulmonary resuscitation with vasopressin in pigs. Wenzel, V., Lindner, K.H., Krismer, A.C., Voelckel, W.G., Schocke, M.F., Hund, W., Witkiewicz, M., Miller, E.A., Klima, G., Wissel, J., Lingnau, W., Aichner, F.T. J. Am. Coll. Cardiol. (2000) [Pubmed]
  34. Magnetic resonance imaging findings associated with cardiac arrest. Roine, R.O., Raininko, R., Erkinjuntti, T., Ylikoski, A., Kaste, M. Stroke (1993) [Pubmed]
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