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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Detection of thyroid tumour using a monoclonal 123I anti-human thyroglobulin antibody.

A monoclonal antibody to human thyroglobulin was radiolabelled with 123I NaI and shown to be a stable and biologically active reagent in vivo. When injected intravenously into 12 patients with cancer of the thyroid on thyroxine-replacement therapy, 6 of the 12 patients had localization of the labelled antibody in tumour sites. These results were compared to 131I scans done on the same patients 1 month after stopping thyroxine. The biological half-life of the antibody in the blood was influenced by the levels of circulating thyroglobulin.[1]

References

  1. Detection of thyroid tumour using a monoclonal 123I anti-human thyroglobulin antibody. Shepherd, P.S., Lazarus, C.R., Mistry, R.D., Maisey, M.N. European journal of nuclear medicine. (1985) [Pubmed]
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