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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Comparative toxic effect of sumithion on rat and pigeon at the level of myelin.

Both rats and pigeons treated with sumithion, an organophosphorous pesticide, at a daily oral dose of one-tenth of the LD50, die after the 6th exposure. In spinal cord myelin of pigeon cerebroside, sulphatide and total protein contents decrease by 30, 15.7 and 40.8%, respectively, and cholesterol increases by 30% after 5 days of treatment; that of the rat shows none of these changes. Densitometric scannings of sodium dodecylsulphate-polyacrylamide gels of myelin proteins show a decrease in Wolfgram and proteolipid protein in rats and in pigeons up to 3 days; after 5 days this change continues only in pigeons, whereas rats show a normal pattern. The proteolipid protein and basic protein of both the species show increased mobility towards the anode up to 3 days, whereas after 5 days this trend continues in pigeons but not in rats.[1]


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