The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Plp1  -  proteolipid protein 1

Rattus norvegicus

Synonyms: Lipophilin, Myelin proteolipid protein, PLP, Plp
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Plp


High impact information on Plp


Chemical compound and disease context of Plp


Biological context of Plp


Anatomical context of Plp


Associations of Plp with chemical compounds


Regulatory relationships of Plp


Other interactions of Plp


Analytical, diagnostic and therapeutic context of Plp


  1. Conduction abnormalities are restricted to the central nervous system in experimental autoimmune encephalomyelitis induced by inoculation with proteolipid protein but not with myelin basic protein. Chalk, J.B., McCombe, P.A., Pender, M.P. Brain (1994) [Pubmed]
  2. Myelination delay in the cerebral white matter of immature rats with kaolin-induced hydrocephalus is reversible. Del Bigio, M.R., Kanfer, J.N., Zhang, Y.W. J. Neuropathol. Exp. Neurol. (1997) [Pubmed]
  3. Selective effect of hypothyroidism on expression of myelin markers during development. Barradas, P.C., Vieira, R.S., De Freitas, M.S. J. Neurosci. Res. (2001) [Pubmed]
  4. A novel mutation (A246T) in exon 6 of the proteolipid protein gene associated with connatal Pelizaeus-Merzbacher disease. Yamamoto, T., Nanba, E. Hum. Mutat. (1999) [Pubmed]
  5. Proteolipid protein gene modulates viability and phenotype of neurons. Boucher, S.E., Cypher, M.A., Carlock, L.R., Skoff, R.P. J. Neurosci. (2002) [Pubmed]
  6. Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein. Milner, R.J., Lai, C., Nave, K.A., Lenoir, D., Ogata, J., Sutcliffe, J.G. Cell (1985) [Pubmed]
  7. Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE. Miller, S.D., Vanderlugt, C.L., Lenschow, D.J., Pope, J.G., Karandikar, N.J., Dal Canto, M.C., Bluestone, J.A. Immunity (1995) [Pubmed]
  8. Differentiation and death of premyelinating oligodendrocytes in developing rodent brain. Trapp, B.D., Nishiyama, A., Cheng, D., Macklin, W. J. Cell Biol. (1997) [Pubmed]
  9. Retinoic acid-regulated expression of proteolipid protein and myelin-associated glycoprotein genes in C6 glioma cells. Zhu, W., Kanoh, M., Ye, P., Laszkiewicz, I., Royland, J.E., Wiggins, R.C., Konat, G. J. Neurosci. Res. (1992) [Pubmed]
  10. Stimulation of myelin proteolipid protein gene expression by eicosapentaenoic acid in C6 glioma cells. Salvati, S., Natali, F., Attorri, L., Raggi, C., Di Biase, A., Sanchez, M. Neurochem. Int. (2004) [Pubmed]
  11. Effect of maternal vitamin B-6 restriction on pyridoxal phosphate concentrations in developing regions of the central nervous system in rats. Groziak, S., Kirksey, A., Hamaker, B. J. Nutr. (1984) [Pubmed]
  12. Evidence that some oligodendrocyte progenitors in the developing optic pathway express the plp gene. Fanarraga, M.L., Dickinson, P.J., Sommer, I., Montague, P., Kyriakides, E., Griffiths, I.R. Glia (1996) [Pubmed]
  13. Cloned proteolipid protein and myelin basic protein cDNA. Transcription of the two genes during myelination. Schaich, M., Budzinski, R.M., Stoffel, W. Biol. Chem. Hoppe-Seyler (1986) [Pubmed]
  14. Evidence that the homeodomain protein Gtx is involved in the regulation of oligodendrocyte myelination. Awatramani, R., Scherer, S., Grinspan, J., Collarini, E., Skoff, R., O'Hagan, D., Garbern, J., Kamholz, J. J. Neurosci. (1997) [Pubmed]
  15. Endoplasmic reticulum stress in PLP-overexpressing transgenic rats: gray matter oligodendrocytes are more vulnerable than white matter oligodendrocytes. Bauer, J., Bradl, M., Klein, M., Leisser, M., Deckwerth, T.L., Wekerle, H., Lassmann, H. J. Neuropathol. Exp. Neurol. (2002) [Pubmed]
  16. Effect of cyclic AMP on the expression of myelin basic protein species and myelin proteolipid protein in committed oligodendrocytes: differential involvement of the transcription factor CREB. Afshari, F.S., Chu, A.K., Sato-Bigbee, C. J. Neurosci. Res. (2001) [Pubmed]
  17. Molecular mechanisms involved in the actions of apotransferrin upon the central nervous system: Role of the cytoskeleton and of second messengers. Marta, C.B., Davio, C., Pasquini, L.A., Soto, E.F., Pasquini, J.M. J. Neurosci. Res. (2002) [Pubmed]
  18. Effects of dexamethasone on the expression of myelin basic protein, proteolipid protein, and glial fibrillary acidic protein genes in developing rat brain. Tsuneishi, S., Takada, S., Motoike, T., Ohashi, T., Sano, K., Nakamura, H. Brain Res. Dev. Brain Res. (1991) [Pubmed]
  19. Myelin-deficient rat: a point mutation in exon III (A----C, Thr75----Pro) of the myelin proteolipid protein causes dysmyelination and oligodendrocyte death. Boison, D., Stoffel, W. EMBO J. (1989) [Pubmed]
  20. Differential regulation of oligodendrocyte markers by glucocorticoids: post-transcriptional regulation of both proteolipid protein and myelin basic protein and transcriptional regulation of glycerol phosphate dehydrogenase. Kumar, S., Cole, R., Chiappelli, F., de Vellis, J. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  21. Expression of myelin proteolipid and basic protein mRNAs in cultured cells. Macklin, W.B., Weill, C.L., Deininger, P.L. J. Neurosci. Res. (1986) [Pubmed]
  22. Clinical and histological findings in proteolipid protein-induced experimental autoimmune encephalomyelitis (EAE) in the Lewis rat. Distribution of demyelination differs from that in EAE induced by other antigens. Chalk, J.B., McCombe, P.A., Smith, R., Pender, M.P. J. Neurol. Sci. (1994) [Pubmed]
  23. Developmental expression of myelin proteolipid, basic protein, and 2',3'-cyclic nucleotide 3'-phosphodiesterase transcripts in different rat brain regions. Kanfer, J., Parenty, M., Goujet-Zalc, C., Monge, M., Bernier, L., Campagnoni, A.T., Dautigny, A., Zalc, B. J. Mol. Neurosci. (1989) [Pubmed]
  24. Calpain inhibitor prevented apoptosis and maintained transcription of proteolipid protein and myelin basic protein genes in rat spinal cord injury. Ray, S.K., Matzelle, D.D., Sribnick, E.A., Guyton, M.K., Wingrave, J.M., Banik, N.L. J. Chem. Neuroanat. (2003) [Pubmed]
  25. Nuclear organization in differentiating oligodendrocytes. Nielsen, J.A., Hudson, L.D., Armstrong, R.C. J. Cell. Sci. (2002) [Pubmed]
  26. Insulin-like growth factor I treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis. Yao, D.L., Liu, X., Hudson, L.D., Webster, H.D. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  27. Induction of anti-myelin antibodies in EAE and their possible role in demyelination. Sadler, R.H., Sommer, M.A., Forno, L.S., Smith, M.E. J. Neurosci. Res. (1991) [Pubmed]
  28. OLN-93: a new permanent oligodendroglia cell line derived from primary rat brain glial cultures. Richter-Landsberg, C., Heinrich, M. J. Neurosci. Res. (1996) [Pubmed]
  29. Role for the oligodendrocyte cytoskeleton in myelination. Wilson, R., Brophy, P.J. J. Neurosci. Res. (1989) [Pubmed]
  30. Active and passive experimental autoimmune encephalomyelitis in strain 129/J (H-2b) mice. Fritz, R.B., Zhao, M.L. J. Neurosci. Res. (1996) [Pubmed]
WikiGenes - Universities