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Amuro, Y. et al.

Reduction of 7-ketolithocholic acid to chenodeoxycholic acid by rat liver preparations in vitro.

The formation of chenodeoxycholic acid via 7-ketolithocholic acid by rat liver preparations was examined in vitro. Results showed that a rat liver preparation reduced 7-ketolithocholic acid mainly to chenodeoxycholic acid and to ursodeoxycholic acid in a smaller amount, and that the reductase required NADPH but not NADH as coenzyme and was mainly localized in the microsomes.[1]

References

Reduction of 7-ketolithocholic acid to chenodeoxycholic acid by rat liver preparations in vitro. Amuro, Y., Yamade, W., Nakano, T., Hayashi, E., Hada, T., Higashino, K. Biochim. Biophys. Acta (1985) [Pubmed]

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