Disease relevance of NSC 226118

• These observations suggest that 7-ketolithocholic acid is an intermediate of this biotransformation in patients with Crohn's disease [1].
• In the bile of the hamsters with bile fistula, radioactivity was originated from unchanged chenodeoxycholic acid for the most part, and 7-ketolithocholic acid, lithocholic acid, and beta-muricholic acid for the remainder [2].

High impact information on NSC 226118

• Guinea pig gallbladder bile contains chenodeoxycholic acid (62 +/- 5%), ursodeoxycholic acid (8 +/- 5%), and 7-ketolithocholic acid (30 +/- 5%) [3].
• Ursodeoxycholic acid, chenodeoxycholic acid, and 7-ketolithocholic acid are primary bile acids of the guinea pig [3].
• Feeding CDA to animals without cecum and appendix (group IV) resulted in a slight increase of LA (3.2 +/- 2.2%) compared to group III, and appreciable amounts of ursodeoxycholic acid (UDA) 32.0 +/- 9.8% and of 7-ketolithocholic acid (7-KLA) 3.0 +/- 0.6% appeared in bile [4].
• Liver preparations were incubated with 7-ketolithocholic acid at pH 5.5 in a sodium-potassium-phosphate buffer containing NADPH or NADH [5].
• Absorption of 7-ketolithocholic acid in rat jejunum, ileum and colon [6].

Biological context of NSC 226118

• The excellent colonic absorption of 7-ketolithocholic acid demonstrates, that not only the small intestine but also the colon contributes to the enterohepatic circulation of bile acids [6].

Anatomical context of NSC 226118

• In the present study absorption of 7-ketolithocholic acid in jejunum, ileum, and colon was measured [6].

Associations of NSC 226118 with other chemical compounds

• Reduction of 7-ketolithocholic acid to chenodeoxycholic acid by rat liver preparations in vitro [7].

References