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Chemical Compound Review

NSC-683769     (4R)-4- [(3R,5S,8S,9S,10S,13R,14S,17R) -3,7...

Synonyms: AC1L8WFY, CTK8E0426, NSC683769
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Disease relevance of URSODEOXYCHOLIC ACID


Psychiatry related information on URSODEOXYCHOLIC ACID


High impact information on URSODEOXYCHOLIC ACID


Chemical compound and disease context of URSODEOXYCHOLIC ACID


Biological context of URSODEOXYCHOLIC ACID


Anatomical context of URSODEOXYCHOLIC ACID


Associations of URSODEOXYCHOLIC ACID with other chemical compounds




Analytical, diagnostic and therapeutic context of URSODEOXYCHOLIC ACID


  1. Ursodiol for the long-term treatment of primary biliary cirrhosis. The UDCA-PBC Study Group. Poupon, R.E., Poupon, R., Balkau, B. N. Engl. J. Med. (1994) [Pubmed]
  2. Effects of ursodeoxycholic acid and aspirin on the formation of lithogenic bile and gallstones during loss of weight. Broomfield, P.H., Chopra, R., Sheinbaum, R.C., Bonorris, G.G., Silverman, A., Schoenfield, L.J., Marks, J.W. N. Engl. J. Med. (1988) [Pubmed]
  3. Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis. Beuers, U., Nathanson, M.H., Isales, C.M., Boyer, J.L. J. Clin. Invest. (1993) [Pubmed]
  4. Intravenous ursodeoxycholic acid reduces cholestasis in parenterally fed newborn piglets. Duerksen, D.R., Van Aerde, J.E., Gramlich, L., Meddings, J.B., Chan, G., Thomson, A.B., Clandinin, M.T. Gastroenterology (1996) [Pubmed]
  5. High-dose ursodeoxycholic acid in primary sclerosing cholangitis: a 5-year multicenter, randomized, controlled study. Olsson, R., Boberg, K.M., de Muckadell, O.S., Lindgren, S., Hultcrantz, R., Folvik, G., Bell, H., Gangsøy-Kristiansen, M., Matre, J., Rydning, A., Wikman, O., Danielsson, A., Sandberg-Gertzén, H., Ung, K.A., Eriksson, A., Lööf, L., Prytz, H., Marschall, H.U., Broomé, U. Gastroenterology (2005) [Pubmed]
  6. Ursodeoxycholic therapy in chronic liver disease: a meta-analysis in primary biliary cirrhosis and in chronic hepatitis. Simko, V., Michael, S., Prego, V. Am. J. Gastroenterol. (1994) [Pubmed]
  7. Natural history of pruritus in primary biliary cirrhosis. Talwalkar, J.A., Souto, E., Jorgensen, R.A., Lindor, K.D. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. (2003) [Pubmed]
  8. High-dose steroids, ursodeoxycholic acid, and chronic intravenous antibiotics improve bile flow after Kasai procedure in infants with biliary atresia. Meyers, R.L., Book, L.S., O'Gorman, M.A., Jackson, W.D., Black, R.E., Johnson, D.G., Matlak, M.E. J. Pediatr. Surg. (2003) [Pubmed]
  9. Intrahepatic cholestatic syndromes: pathogenesis, clinical features and management. Qureshi, W.A. Digestive diseases (Basel, Switzerland) (1999) [Pubmed]
  10. Ursodiol for primary sclerosing cholangitis. Mayo Primary Sclerosing Cholangitis-Ursodeoxycholic Acid Study Group. Lindor, K.D. N. Engl. J. Med. (1997) [Pubmed]
  11. Fragmentation of gallstones by extracorporeal shock waves. Sauerbruch, T., Delius, M., Paumgartner, G., Holl, J., Wess, O., Weber, W., Hepp, W., Brendel, W. N. Engl. J. Med. (1986) [Pubmed]
  12. A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. Rodrigues, C.M., Fan, G., Ma, X., Kren, B.T., Steer, C.J. J. Clin. Invest. (1998) [Pubmed]
  13. Chronic ursodeoxycholic acid- and chenodeoxycholic acid-feeding-induced changes of colon mucosal cell proliferation in rats. Simanowski, U.A., Seitz, H.K., Czygan, P., Hörner, M., Waldherr, R., Weber, E., Kommerell, B. J. Natl. Cancer Inst. (1987) [Pubmed]
  14. 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Fickert, P., Wagner, M., Marschall, H.U., Fuchsbichler, A., Zollner, G., Tsybrovskyy, O., Zatloukal, K., Liu, J., Waalkes, M.P., Cover, C., Denk, H., Hofmann, A.F., Jaeschke, H., Trauner, M. Gastroenterology (2006) [Pubmed]
  15. A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBC Study Group. Poupon, R.E., Balkau, B., Eschwège, E., Poupon, R. N. Engl. J. Med. (1991) [Pubmed]
  16. Transformation of chenodeoxycholic acid to ursodeoxycholic acid in patients with Crohn's disease. Miwa, H., Yamamoto, M., Nishida, T., Yao, T. Gastroenterology (1986) [Pubmed]
  17. Comparative formation of lithocholic acid from chenodeoxycholic and ursodeoxycholic acids in the colon. Bazzoli, F., Fromm, H., Sarva, R.P., Sembrat, R.F., Ceryak, S. Gastroenterology (1982) [Pubmed]
  18. Drug-associated acute-onset vanishing bile duct and Stevens-Johnson syndromes in a child. Srivastava, M., Perez-Atayde, A., Jonas, M.M. Gastroenterology (1998) [Pubmed]
  19. Differing effects of nor-ursodeoxycholic or ursodeoxycholic acid on hepatic histology and bile acid metabolism in the rabbit. Cohen, B.I., Hofmann, A.F., Mosbach, E.H., Stenger, R.J., Rothschild, M.A., Hagey, L.R., Yoon, Y.B. Gastroenterology (1986) [Pubmed]
  20. Metabolism, pharmacokinetics, and activity of a new 6-fluoro analogue of ursodeoxycholic acid in rats and hamsters. Roda, A., Pellicciari, R., Polimeni, C., Cerrè, C., Forti, G.C., Sadeghpour, B., Sapigni, E., Gioacchini, A.M., Natalini, B. Gastroenterology (1995) [Pubmed]
  21. Intestinal absorption of ursodeoxycholic acid in patients with extrahepatic biliary obstruction and bile drainage. Walker, S., Rudolph, G., Raedsch, R., Stiehl, A. Gastroenterology (1992) [Pubmed]
  22. Tauroursodeoxycholate increases rat liver ursodeoxycholate levels and limits lithocholate formation better than ursodeoxycholate. Rodrigues, C.M., Kren, B.T., Steer, C.J., Setchell, K.D. Gastroenterology (1995) [Pubmed]
  23. Comparative effects of ursodeoxycholic acid and chenodeoxycholic acid on bile acid kinetics and biliary lipid secretion in humans. Evidence for different modes of action on bile acid synthesis. Nilsell, K., Angelin, B., Leijd, B., Einarsson, K. Gastroenterology (1983) [Pubmed]
  24. Expression of HLA molecules on hepatocytes: does ursodeoxycholic acid prevent immunologic injury? Borum, M., Fromm, H. Gastroenterology (1990) [Pubmed]
  25. Ursodeoxycholic acid limits liver histologic alterations and portal hypertension induced by bile duct ligation in the rat. Poo, J.L., Feldmann, G., Erlinger, S., Braillon, A., Gaudin, C., Dumont, M., Lebrec, D. Gastroenterology (1992) [Pubmed]
  26. Acute effects of ursodeoxycholic and chenodeoxycholic acid on the small intestinal absorption of bile acids. Stiehl, A., Raedsch, R., Rudolph, G. Gastroenterology (1990) [Pubmed]
  27. Effect of tauroursodeoxycholic and ursodeoxycholic acid on ethanol-induced cell injuries in the human Hep G2 cell line. Neuman, M.G., Cameron, R.G., Shear, N.H., Bellentani, S., Tiribelli, C. Gastroenterology (1995) [Pubmed]
  28. The site-specific delivery of ursodeoxycholic acid to the rat colon by sulfate conjugation. Rodrigues, C.M., Kren, B.T., Steer, C.J., Setchell, K.D. Gastroenterology (1995) [Pubmed]
  29. Gallbladder motility in cholesterol gallstone disease. Effect of ursodeoxycholic acid administration and gallstone dissolution. Festi, D., Frabboni, R., Bazzoli, F., Sangermano, A., Ronchi, M., Rossi, L., Parini, P., Orsini, M., Primerano, A.M., Mazzella, G. Gastroenterology (1990) [Pubmed]
  30. Ursodeoxycholic acid and cholesterol induce enterohepatic cycling of bilirubin in rodents. Méndez-Sánchez, N., Brink, M.A., Paigen, B., Carey, M.C. Gastroenterology (1998) [Pubmed]
  31. Bile acids substituted in the 6 position prevent cholesterol gallstone formation in the hamster. Cohen, B.I., Matoba, N., Mosbach, E.H., Ayyad, N., Hakam, K., Suh, S.O., McSherry, C.K. Gastroenterology (1990) [Pubmed]
  32. An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity. Fiorucci, S., Mencarelli, A., Palazzetti, B., Del Soldato, P., Morelli, A., Ignarro, L.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  33. Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes. Qiao, L., Yacoub, A., Studer, E., Gupta, S., Pei, X.Y., Grant, S., Hylemon, P.B., Dent, P. Hepatology (2002) [Pubmed]
  34. Ursodeoxycholic acid modulates E2F-1 and p53 expression through a caspase-independent mechanism in transforming growth factor beta1-induced apoptosis of rat hepatocytes. Sola, S., Ma, X., Castro, R.E., Kren, B.T., Steer, C.J., Rodrigues, C.M. J. Biol. Chem. (2003) [Pubmed]
  35. Differences in the regulation of the classical and the alternative pathway for bile acid synthesis in human liver. No coordinate regulation of CYP7A1 and CYP27A1. Björkhem, I., Araya, Z., Rudling, M., Angelin, B., Einarsson, C., Wikvall, K. J. Biol. Chem. (2002) [Pubmed]
  36. Treatment with ursodeoxycholic acid renders children with biliary atresia suitable for liver transplantation. Ullrich, D., Rating, D., Schröter, W., Hanefeld, F., Bircher, J. Lancet (1987) [Pubmed]
  37. Dissolution of cholesterol gallstones by ursodeoxycholic acid. Nakagawa, S., Makino, I., Ishizaki, T., Dohi, I. Lancet (1977) [Pubmed]
  38. Gallbladder motility before and after extracorporeal shock-wave lithotripsy. Spengler, U., Sackmann, M., Sauerbruch, T., Holl, J., Paumgartner, G. Gastroenterology (1989) [Pubmed]
  39. Intestinal failure-associated liver disease: what do we know today? Kelly, D.A. Gastroenterology (2006) [Pubmed]
  40. Serum concentrations of ursodeoxycholic acid in portal venous and systemic venous blood of fasting humans as determined by isotope dilution-mass spectrometry. Ewerth, S., Angelin, B., Einarsson, K., Nilsell, K., Björkhem, I. Gastroenterology (1985) [Pubmed]
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