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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Enzymatic denitrification of 2-nitropropane in uninduced mouse liver microsomes.

Hepatic microsomes from 5 strains of untreated mice were tested for the ability to enzymatically cleave the nitro group from 2-nitropropane (2NP). All strains showed significant NADPH-dependent nitrite release at pH 7.6 and pH 8. 8. Statistical differences in nitrite-releasing activity between strains were found between BALB and PL/J and ATH strains at pH 7. 6. At pH 8.8, BIO.M differed from CD-1 and BALB. These results are in contrast to a report of little or no denitrification activity in uninduced rats and suggest that the 2NP microsomal metabolism may be of greater importance than previously thought.[1]

References

  1. Enzymatic denitrification of 2-nitropropane in uninduced mouse liver microsomes. Marker, E.K., Kulkarni, A.P. Toxicol. Lett. (1985) [Pubmed]
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