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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Pancreatic polypeptide: a marker for lean non-insulin-dependent diabetes mellitus?

Both basal and postprandial pancreatic polypeptide ( PP) concentrations were exaggerated twofold in lean NIDDM patients, whereas they were normal in lean IDDM and obese NIDDM patients who were hyperglycemic as a result of partial insulin withdrawal. Insulin infusion from an artificial endocrine pancreas, which resulted in fasting euglycemia and near-normoglycemia postprandially, had no effect on PP responses in any of the diabetic patients. No postprandial PP responses were observed in totally pancreatectomized ( TPX) patients. Excessive basal and postprandial concentrations of PP in diabetes appear to be related to both leanness and residual beta cell function and, therefore, potential markers for lean NIDDM.[1]

References

  1. Pancreatic polypeptide: a marker for lean non-insulin-dependent diabetes mellitus? Service, F.J., Koch, M.B., Jay, J.M., Rizza, R.A., Go, V.L. Diabetes Care (1985) [Pubmed]
 
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