Gene Review:
IDDM2 - insulin-dependent diabetes mellitus 2
Homo sapiens
This record was replaced with 3630.
She,
Marron,
Concannon,
Gogolin-Ewens,
Hinds,
Wapelhorst,
Morrison,
Stirling,
Mitra,
Farmer,
Williams,
Cox,
Bell,
Risch,
Spielman,
Pugliese,
Zeller,
Fernandez,
Zalcberg,
Bartlett,
Ricordi,
Pietropaolo,
Eisenbarth,
Bennett,
Patel,
Ueki,
Isozaki,
Kusaka,
Hermann,
Knip,
Veijola,
Simell,
Laine,
Akerblom,
Groop,
Forsblom,
Pettersson-Fernholm,
Ilonen,
Stead,
Buard,
Todd,
Jeffreys,
Cornélis,
Fauré,
Martinez,
Prud'homme,
Fritz,
Dib,
Alves,
Barrera,
de Vries,
Balsa,
Pascual-Salcedo,
Maenaut,
Westhovens,
Migliorini,
Tran,
Delaye,
Prince,
Lefevre,
Thomas,
Poirier,
Soubigou,
Alibert,
Lasbleiz,
Fouix,
Bouchier,
Lioté,
Loste,
Lepage,
Charron,
Gyapay,
Lopes-Vaz,
Kuntz,
Bardin,
Weissenbach,
Imagawa,
Hanafusa,
Miyagawa,
Matsuzawa,
- Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes. Stead, J.D., Buard, J., Todd, J.A., Jeffreys, A.J. Hum. Mol. Genet. (2000)
- Autoimmune polyglandular syndromes. Obermayer-Straub, P., Manns, M.P. Baillieres Clin. Gastroenterol. (1998)
- Screening for an AIRE-1 mutation in patients with Addison's disease, type 1 diabetes, Graves' disease and Hashimoto's thyroiditis as well as in APECED syndrome. Meyer, G., Donner, H., Herwig, J., Böhles, H., Usadel, K.H., Badenhoop, K. Clin. Endocrinol. (Oxf) (2001)
- Variants in the human insulin gene that affect pre-mRNA splicing: is -23HphI a functional single nucleotide polymorphism at IDDM2? Královicová, J., Gaunt, T.R., Rodriguez, S., Wood, P.J., Day, I.N., Vorechovsky, I. Diabetes (2006)
- New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study. Cornélis, F., Fauré, S., Martinez, M., Prud'homme, J.F., Fritz, P., Dib, C., Alves, H., Barrera, P., de Vries, N., Balsa, A., Pascual-Salcedo, D., Maenaut, K., Westhovens, R., Migliorini, P., Tran, T.H., Delaye, A., Prince, N., Lefevre, C., Thomas, G., Poirier, M., Soubigou, S., Alibert, O., Lasbleiz, S., Fouix, S., Bouchier, C., Lioté, F., Loste, M.N., Lepage, V., Charron, D., Gyapay, G., Lopes-Vaz, A., Kuntz, D., Bardin, T., Weissenbach, J. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Aberrant parasympathetic and hemodynamic function distinguishes a subgroup of psychologically distressed individuals with asymptomatic type-I diabetes mellitus. Motivala, S.J., Hurwitz, B.E., LaGreca, A.M., Llabre, M.M., Marks, J.B., Skyler, J.S., Schneiderman, N. International journal of behavioral medicine. (1999)
- Disordered eating behavior and microvascular complications in young women with insulin-dependent diabetes mellitus. Rydall, A.C., Rodin, G.M., Olmsted, M.P., Devenyi, R.G., Daneman, D. N. Engl. J. Med. (1997)
- Long-term intermittent intravenous insulin therapy and type 1 diabetes mellitus. Aoki, T.T., Benbarka, M.M., Okimura, M.C., Arcangeli, M.A., Walter, R.M., Wilson, L.D., Truong, M.P., Barber, A.R., Kumagai, L.F. Lancet (1993)
- Abnormalities of cognitive functions in IDDM revealed by P300 event-related potential analysis. Comparison with short-latency evoked potentials and psychometric tests. Pozzessere, G., Valle, E., de Crignis, S., Cordischi, V.M., Fattapposta, F., Rizzo, P.A., Pietravalle, P., Cristina, G., Morano, S., di Mario, U. Diabetes (1991)
- A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. Osaka IDDM Study Group. Imagawa, A., Hanafusa, T., Miyagawa, J., Matsuzawa, Y. N. Engl. J. Med. (2000)
- A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus. Concannon, P., Gogolin-Ewens, K.J., Hinds, D.A., Wapelhorst, B., Morrison, V.A., Stirling, B., Mitra, M., Farmer, J., Williams, S.R., Cox, N.J., Bell, G.I., Risch, N., Spielman, R.S. Nat. Genet. (1998)
- The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Pugliese, A., Zeller, M., Fernandez, A., Zalcberg, L.J., Bartlett, R.J., Ricordi, C., Pietropaolo, M., Eisenbarth, G.S., Bennett, S.T., Patel, D.D. Nat. Genet. (1997)
- Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Vafiadis, P., Bennett, S.T., Todd, J.A., Nadeau, J., Grabs, R., Goodyer, C.G., Wickramasinghe, S., Colle, E., Polychronakos, C. Nat. Genet. (1997)
- Linkage and association between insulin-dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7. Rowe, R.E., Wapelhorst, B., Bell, G.I., Risch, N., Spielman, R.S., Concannon, P. Nat. Genet. (1995)
- HLA-DQB1 alleles and absence of Asp 57 as susceptibility factors of IDDM in Finland. Reijonen, H., Ilonen, J., Knip, M., Akerblom, H.K. Diabetes (1991)
- Anti-caspase-8 autoantibody response in silicosis patients is associated with HLA-DRB1, DQB1 and DPB1 alleles. Ueki, A., Isozaki, Y., Kusaka, M. Journal of occupational health. (2005)
- Clinical studies of IGFBP-2 by radioimmunoassay. Blum, W.F., Horn, N., Kratzsch, J., Jørgensen, J.O., Juul, A., Teale, D., Mohnike, K., Ranke, M.B. Growth Regul. (1993)
- A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA. Kadowaki, T., Kadowaki, H., Mori, Y., Tobe, K., Sakuta, R., Suzuki, Y., Tanabe, Y., Sakura, H., Awata, T., Goto, Y. N. Engl. J. Med. (1994)
- Genetic susceptibility factors in type 1 diabetes: linkage, disequilibrium and functional analyses. She, J.X., Marron, M.P. Curr. Opin. Immunol. (1998)
- Multifactorial inheritance in type 1 diabetes. Cordell, H.J., Todd, J.A. Trends Genet. (1995)
- Two-locus maximum lod score analysis of a multifactorial trait: joint consideration of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes. Cordell, H.J., Todd, J.A., Bennett, S.T., Kawaguchi, Y., Farrall, M. Am. J. Hum. Genet. (1995)
- Panning for gold: genome-wide scanning for linkage in type 1 diabetes. Todd, J.A., Farrall, M. Hum. Mol. Genet. (1996)
- Divergence between genetic determinants of IGF2 transcription levels in leukocytes and of IDDM2-encoded susceptibility to type 1 diabetes. Vafiadis, P., Bennett, S.T., Todd, J.A., Grabs, R., Polychronakos, C. J. Clin. Endocrinol. Metab. (1998)
- Genetics of type 1A diabetes. Redondo, M.J., Fain, P.R., Eisenbarth, G.S. Recent Prog. Horm. Res. (2001)
- Imprinted and genotype-specific expression of genes at the IDDM2 locus in pancreas and leucocytes. Vafiadis, P., Bennett, S.T., Colle, E., Grabs, R., Goodyer, C.G., Polychronakos, C. J. Autoimmun. (1996)
- Two genetic loci regulate T cell-dependent islet inflammation and drive autoimmune diabetes pathogenesis. Fox, C.J., Paterson, A.D., Mortin-Toth, S.M., Danska, J.S. Am. J. Hum. Genet. (2000)
- Association of HLA-A24 with complete beta-cell destruction in IDDM. Nakanishi, K., Kobayashi, T., Murase, T., Nakatsuji, T., Inoko, H., Tsuji, K., Kosaka, K. Diabetes (1993)
- A functional analysis of the role of IGF2 in IDDM2-encoded susceptibility to type 1 diabetes. Vafiadis, P., Grabs, R., Goodyer, C.G., Colle, E., Polychronakos, C. Diabetes (1998)
- HLA-DQB1 codon 57 and IDDM in Chinese living in Taiwan. Chuang, L.M., Jou, T.S., Hu, C.Y., Wu, H.P., Tsai, W.Y., Lee, J.S., Hsieh, R.P., Chen, K.H., Tai, T.Y., Lin, B.J. Diabetes Care (1994)
- Effect of polymorphism in the insulin gene region on IDDM susceptibility and insulin secretion. The Childhood Diabetes in Finland (DiMe) Study Group. Halminen, M., Veijola, R., Reijonen, H., Ilonen, J., Akerblom, H.K., Knip, M. Eur. J. Clin. Invest. (1996)
- The ketosis-resistance in fibro-calculous-pancreatic-diabetes. 1. Clinical observations and endocrine-metabolic measurements during oral glucose tolerance test. Yajnik, C.S., Shelgikar, K.M., Naik, S.S., Kanitkar, S.V., Orskov, H., Alberti, K.G., Hockaday, T.D. Diabetes Res. Clin. Pract. (1992)
- Insulin alleles and autoimmune regulator (AIRE) gene expression both influence insulin expression in the thymus. Sabater, L., Ferrer-Francesch, X., Sospedra, M., Caro, P., Juan, M., Pujol-Borrell, R. J. Autoimmun. (2005)
- Distribution of HLA-DRB1, -DQA1 and -DQB1 alleles and DQA1-DQB1 genotypes among Norwegian patients with insulin-dependent diabetes mellitus. Rønningen, K.S., Spurkland, A., Iwe, T., Vartdal, F., Thorsby, E. Tissue Antigens (1991)
- Contribution of the absence of aspartic acid at position 57 of the HLA-DQ beta chain to predisposition to insulin-dependent diabetes mellitus in a southern Chinese population. Zhang, S., Cheng, H., Fu, Z., Zhong, G., Yan, T. Chin. Med. J. (1998)
- Challenges and strategies for investigating the genetic complexity of common human diseases. Rich, S.S., Concannon, P. Diabetes (2002)
- Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes--indication of an increased environmental pressure? Hermann, R., Knip, M., Veijola, R., Simell, O., Laine, A.P., Akerblom, H.K., Groop, P.H., Forsblom, C., Pettersson-Fernholm, K., Ilonen, J. Diabetologia (2003)
- Autoimmunity to glutamic acid decarboxylase in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). Klemetti, P., Björses, P., Tuomi, T., Perheentupa, J., Partanen, J., Rautonen, N., Hinkkanen, A., Ilonen, J., Vaarala, O. Clin. Exp. Immunol. (2000)
- Preliminary studies on associations of IDDM3, IDDM4, IDDM5 and IDDM8 with IDDM in Chengdu population. Zhoucun, A., Zhang, S., Xiao, C. Chin. Med. Sci. J. (2001)
- Significance of cow's milk protein antibodies as risk factor for childhood IDDM: interactions with dietary cow's milk intake and HLA-DQB1 genotype. Childhood Diabetes in Finland Study Group. Saukkonen, T., Virtanen, S.M., Karppinen, M., Reijonen, H., Ilonen, J., Räsänen, L., Akerblom, H.K., Savilahti, E. Diabetologia (1998)
- Insulin gene in diabetes. Analysis through RFLP. Permutt, M.A., Elbein, S.C. Diabetes Care (1990)