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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Observations on the elimination of water from 2-hydroxy acids in the metabolism of amino acids by Clostridium sporogenes.

Cell-free extracts of Clostridium sporogenes catalyse the water elimination from (2R)-phenyllactate in the presence of one of the energy-rich compounds acetyl-CoA, acetylphosphate or ATP and coenzyme A. Water is eliminated from (2R)-phenyllactoyl-CoA without any of the aforementioned additions. Cinnamoyl-CoA also acts catalytically. One molecule of cinnamoyl-CoA causes the elimination of water from more than 8 molecules phenyllactate. This is important from an energetic point of view since less than 2 mol ATP are formed per 2-3 mol metabolized amino acids. An activation of the hydroxy group of the alpha-hydroxy acid in form of a phosphate ester can also be excluded for energetic reasons.[1]

References

  1. Observations on the elimination of water from 2-hydroxy acids in the metabolism of amino acids by Clostridium sporogenes. Machacek-Pitsch, C., Rauschenbach, P., Simon, H. Biol. Chem. Hoppe-Seyler (1985) [Pubmed]
 
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