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Chemical Compound Review

Phenyllactate     2-hydroxy-3-phenyl-propanoic acid

Synonyms: SureCN57558, P7251_ALDRICH, AGN-PC-00GTAM, NSC-2627, AG-E-04664, ...
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Disease relevance of C05607


High impact information on C05607


Chemical compound and disease context of C05607


Biological context of C05607

  • In contrast, isoenzyme iLDH-II exhibited broad substrate specificity (lactate, phenyllactate, and 4-hydroxyphenyllactate), but was stereospecific for the L-isomers [10].
  • The conformation of this molecule is compared with that of an analogous compound O-[3-(2,2,5,5-tetramethylpyrrolinyl-1-oxyl)-propen-2-oyl]-L- beta- phenyllactate, which has been employed as a spectroscopic substrate probe of carboxypeptidase A (L. C. Kuo, J. M. Fukuyama, and M. W. Makinen (1983) Journal of Molecular Biology 163, 63-105) [11].

Associations of C05607 with other chemical compounds


  1. Molecular characterization of phenyllactate dehydratase and its initiator from Clostridium sporogenes. Dickert, S., Pierik, A.J., Buckel, W. Mol. Microbiol. (2002) [Pubmed]
  2. Separation of alpha-hydroxy acid enantiomers by high performance capillary electrophoresis using copper(II)-L-amino acid and copper(II)-aspartame complexes as chiral selectors in the background electrolyte. Desiderio, C., Aturki, Z., Fanali, S. Electrophoresis (1994) [Pubmed]
  3. Lactobacillus plantarum MiLAB 393 produces the antifungal cyclic dipeptides cyclo(L-Phe-L-Pro) and cyclo(L-Phe-trans-4-OH-L-Pro) and 3-phenyllactic acid. Ström, K., Sjögren, J., Broberg, A., Schnürer, J. Appl. Environ. Microbiol. (2002) [Pubmed]
  4. The involvement of coenzyme A esters in the dehydration of (R)-phenyllactate to (E)-cinnamate by Clostridium sporogenes. Dickert, S., Pierik, A.J., Linder, D., Buckel, W. Eur. J. Biochem. (2000) [Pubmed]
  5. Measurement of phenyllactate, phenylacetate, and phenylpyruvate by negative ion chemical ionization-gas chromatography/mass spectrometry in brain of mouse genetic models of phenylketonuria and non-phenylketonuria hyperphenylalaninemia. Sarkissian, C.N., Scriver, C.R., Mamer, O.A. Anal. Biochem. (2000) [Pubmed]
  6. From malate dehydrogenase to phenyllactate dehydrogenase. Incorporation of unnatural amino acids to generate an improved enzyme-catalyzed activity. Wright, S.K., Kish, M.M., Viola, R.E. J. Biol. Chem. (2000) [Pubmed]
  7. Transformation of Eutypa dieback and esca disease pathogen toxins by antagonistic fungal strains reveals a second detoxification pathway not present in Vitis vinifera. Christen, D., Tharin, M., Perrin-Cherioux, S., Abou-Mansour, E., Tabacchi, R., Défago, G. J. Agric. Food Chem. (2005) [Pubmed]
  8. Urinary D-4-hydroxyphenyllactate, D-phenyllactate and D-2-hydroxyisocaproate, abnormalities of bacterial origin. Spaapen, L.J., Ketting, D., Wadman, S.K., Bruinvis, L., Duran, M. J. Inherit. Metab. Dis. (1987) [Pubmed]
  9. The stereochemical course of the water elimination from (2R)-phenyllactate in the amino acid fermentation of Clostridium sporogenes. Pitsch, C., Simon, H. Hoppe-Seyler's Z. Physiol. Chem. (1982) [Pubmed]
  10. Neisseria gonorrhoeae possesses two nicotinamide adenine dinucleotide-independent lactate dehydrogenases. Fischer, R.S., Martin, G.C., Rao, P., Jensen, R.A. FEMS Microbiol. Lett. (1994) [Pubmed]
  11. Structure and conformation of the nitroxyl spin-label ethyl 3-(2,2,5,5-tetramethylpyrrolinyl-1-oxyl)-propen-2-oate determined by electron nuclear double resonance: comparison with the structure of a spin-label substrate of carboxypeptidase A. Mustafi, D., Boisvert, W.E., Makinen, M.W. Biopolymers (1990) [Pubmed]
  12. Myelin deficiency in experimental phenylketonuria: contribution of the aromatic acid metabolites of phenylalanine. Loo, Y.H., Scotto, J., Wisniewski, H.M. Adv. Exp. Med. Biol. (1978) [Pubmed]
  13. Cyclic peptides. VIII. Synthesis and tryptic hydrolysis of cyclic depsidipeptides containing a lysine residue. Yasutake, A., Miyazaki, K., Aoyagi, H., Kato, T., Izumiya, N. Int. J. Pept. Protein Res. (1980) [Pubmed]
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