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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Methylthio-capping of selenocysteamine: preliminary studies on selective toxicity for cancer chemotherapy.

Dimethyl disulfide markedly increased the cytotoxicity of selenocystamine by 2 orders of magnitude, from 40 microM to 0.5 microM for 50% inhibition of growth in 45 hr. When mice were injected ip with 22 microMole/Kg of selenocystamine on Day 0, all were dead on Day 4. If dimethyl disulfide (500 microMole/Kg) was either mixed with the selenocystamine or injected immediately prior to it, the mice survived treatment for at least 21 days afterwards, suggesting that methylthio-capping of selenocysteamine reduced host toxicity. Such combined treatment may be of value in chemotherapy.[1]

References

  1. Methylthio-capping of selenocysteamine: preliminary studies on selective toxicity for cancer chemotherapy. Pierson, H.F., Fisher, J.M., Rabinovitz, M. Res. Commun. Chem. Pathol. Pharmacol. (1985) [Pubmed]
 
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