Disease relevance of NSC308820

• Inhibition of influenza A virus replication by rifampicin and selenocystamine [1].
• The effects of selenocystamine, an inhibitor of influenza virus RNA-dependent RNA polymerase in vitro activity, in the antibiotic rifampicin were studied on influenza A/PR/8/34 (HON1) infection in embryonated eggs [1].
• If dimethyl disulfide (500 microMole/Kg) was either mixed with the selenocystamine or injected immediately prior to it, the mice survived treatment for at least 21 days afterwards, suggesting that methylthio-capping of selenocysteamine reduced host toxicity [2].

High impact information on NSC308820

• Cystamine (IC50 = 128 microM) and selenocystamine (IC50 = 13 microM) are the most potent compounds tested [3].
• In keratinocytes, apoptosis may be initiated by superoxide (O2*-) and oxidative free radicals that are generated by selenite and selenocystamine, but not by selenomethionine [4].
• Selenocystamine oxidized protein thiol groups in isolated mitochondria and crude extracts of HepG2 cells but not in intact HepG2 cells, suggesting that this compound is not able to cross the cell membrane [5].
• Such free radical mechanisms may explain much of the cytotoxicity of alkylselenols, and they demonstrate that selenocystamine is a poor catalytic model of the enzyme glutathione peroxidase [6].
• The oxidative deamination is thus the first step of a series of cyclic reactions which give rise to extensive cleavage of selenocystamine [7].

References