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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The Zurich Study. VI. A continuum from depression to anxiety disorders?

A representative sample of 456 persons from the normal population aged 22 and 23 years was used to study the overlap of depression with anxiety disorders. The 1-year prevalence rate for major depression (DSM-III), minor depression, and anxiety disorder together was 16.4%. The observed cases of major depression occurred in 36% with anxiety disorder, the cases with minor depression in 60%. On the level of symptoms assessed by a semistructured clinical interview and on the level of self-assessed items of the symptom check list SCL-90, the overlap was even greater. The main finding was that subjects with both diagnoses, depression and anxiety disorder, were more severely affected in general. Discriminant analyses of the SCL-90 scales together with the qualitative distribution of SCL items characterizing depression, anxiety, or phobia, did not disprove the hypothesis of a continuum.[1]


  1. The Zurich Study. VI. A continuum from depression to anxiety disorders? Angst, J., Dobler-Mikola, A. European archives of psychiatry and neurological sciences. (1985) [Pubmed]
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