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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Elliott, R.B. et al.

Medical manipulation of the ductus arteriosus.

Prostaglandin E-1 was infused into two children with cyanotic congenital heart-disease where patency of the ductus arteriosus was necessary to maintain arterial oxygen saturation. With each infusion oxygen saturation rose, probably as a result of dilatation of the ductus. Administration of the non-specific antagonist of prostaglandin synthesis, indomethacin, to one patient was associated with a fall in arterial saturation. The prevention of ductus closure by p.g.E-1 infusions over the first few weeks of life is a possiblility.[1]

References

Medical manipulation of the ductus arteriosus. Elliott, R.B., Starling, M.B., Neutze, J.M. Lancet (1975) [Pubmed]

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