The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effects of the cholesterol biosynthesis inhibitor ay9944 on organotypic cultures ofmouse spinal cord. Retarded myelinogenesis and induction of cytoplasmic inclusions.

Young cultures of fetal mouse spinal cord were exposed to nutrient medium containingAY9944 [trans-1,4-bis(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride], apotent cholesterol biosynthesis inhibitor, and their reactions were studied by light and electron microscopy. AY9944 treatment for 4 to 7 days retarded cultures revealed anaccumulation of numerous intracytoplasmic inclusions in perikarya of neurons, astrocytes,and oligodendrocytes. These inclusions were also found in dendritic processes, myelinated axons, and presynaptic terminals. These inclusions were composed of concentric lamellar structures or of reticular internal structures. Although considerable improvement of myelination and diminution of cytoplasmic inclusions were noted following the removal of the inhibitor and the restitution in normal nutrient medium, a complete recovery oflesions was not observed during the 3-week restitution period in vitro.[1]


WikiGenes - Universities