The management of hypoparathyroidism with 1alpha-hydroxyvitamin D3.
A retrospective study of the comparative effects of vitamin D, dihydrotachysterol and 1alpha-hydroxyvitamin D3 was undertaken in twenty-eight patients with hypoparathyroidism. The vitamin D compounds restored plasma calcium to the normal range in most patients with comparable actions on the gut, bone and kidney. Although the vitamin D compounds had a direct action on kidney and bone in the absence of PTH, the major action in maintaining plasma calcium was on the gut. Plasma phosphate fell due to a reduction in renal tubular reabsorption. Dihydrotachysterol and 1alpha-hydroxyvitamin D3 had significant practical advantages over vitamin D in their rapid onset of action and their relatively short biological half-life.[1]References
- The management of hypoparathyroidism with 1alpha-hydroxyvitamin D3. Heyburn, P.J., Peacock, M. Clin. Endocrinol. (Oxf) (1977) [Pubmed]
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