The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Oxydevit     (1R,3R,5Z)-5-[(2E)-2- [(1R,7aR)-7a-methyl-1...

Synonyms: Etalpha, Oksidevit, Sinovul, alfacalcidol, Alphacalcidol, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Alfarol


High impact information on Alfarol


Chemical compound and disease context of Alfarol


Biological context of Alfarol

  • To account for the observed clinical response to 1 alpha OHD3 (alpha-calcidol) in follicular NHL a network is suggested whereby 1,25(OH)2D3 modulates the activity of CD4+T cells which have previously been shown to promote follicle centre cell proliferation [1].
  • In a recent study evaluating 145 patients suffering from diseases requiring long-term treatment with high doses of corticosteroids, we have demonstrated a significant benefit of alphacalcidol (1 microg/day) over placebo in terms of changes in bone mineral density of the lumbar spine [16].
  • Hypertension in primary hyperparathyroidism--reduction of blood pressure by long-term treatment with vitamin D (alphacalcidol). A double-blind, placebo-controlled study [17].
  • One alpha B- and three different beta-crystallin cDNA clones were isolated from a chicken lens cDNA library by using anti-crystallin antibodies [18].
  • A total of 79 Japanese women who were within 5 years of menopause were randomly assigned 1alpha-hydroxyvitamin D3 [1alpha(OH)D3] 1.0 microg/day, conjugated estrogens 0.625 mg/day, a combination of both, or control (no treatment) [19].

Anatomical context of Alfarol


Associations of Alfarol with other chemical compounds


Gene context of Alfarol


Analytical, diagnostic and therapeutic context of Alfarol


  1. The effect of 1,25-dihydroxyvitamin D3 on lymphoma cell lines and expression of vitamin D receptor in lymphoma. Hickish, T., Cunningham, D., Colston, K., Millar, B.C., Sandle, J., Mackay, A.G., Soukop, M., Sloane, J. Br. J. Cancer (1993) [Pubmed]
  2. Amelioration of osteopenia and hypovitaminosis D by 1alpha-hydroxyvitamin D3 in elderly patients with Parkinson's disease. Sato, Y., Manabe, S., Kuno, H., Oizumi, K. J. Neurol. Neurosurg. Psychiatr. (1999) [Pubmed]
  3. Bone histomorphometry in patients with chronic renal failure: effect of 1alpha-hydroxyvitamin D3. Melsen, F., Nielsen, H.E., Christensen, M.S. Clin. Endocrinol. (Oxf) (1977) [Pubmed]
  4. Correlation of clinical, biochemical and skeletal responses to 1alpha-hydroxyvitamin D3 in renal bone disease. Kanis, J.A., Earnshaw, M., Henderson, R.G., Heynen, G., Ledingham, J.G., Naik, R.B., Oliver, D.O., Russell, R.G., Smith, R., Wilkinson, R.H., Woods, C.G. Clin. Endocrinol. (Oxf) (1977) [Pubmed]
  5. Spinal calcium changes with 1alpha-hydroxyvitamin D3. Dabek, J.T., Robinson, B.H., Naik, R.B., Al-Hiti, K. Clin. Endocrinol. (Oxf) (1977) [Pubmed]
  6. Expression of two alpha chains on the surface of T cells in T cell receptor transgenic mice. Heath, W.R., Miller, J.F. J. Exp. Med. (1993) [Pubmed]
  7. Jejunal and ileal absorption in patients with chronic renal disease. Effect of 1alpha-hydroxycholecalciferol. Vergne-Marini, P., Parker, T.F., Pak, C.Y., Hull, A.R., DeLuca, H.F., Fordtran, J.S. J. Clin. Invest. (1976) [Pubmed]
  8. Direct C-1 hydroxylation of vitamin D compounds: convenient preparation of 1alpha-hydroxyvitamin D3, 1alpha, 25-dihydroxyvitamin D3, and 1alpha-hydroxyvitamin D2. Paaren, H.E., Hamer, D.E., Schnoes, H.K., DeLuca, H.F. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  9. The effect of 1alpha-hydroxyvitamin D3 administration on calcium transport in chick intestine brush border membrane vesicles. Rasmussen, H., Fontaine, O., Max, E.E., Goodman, D.B. J. Biol. Chem. (1979) [Pubmed]
  10. Metabolism of 1alpha-hydroxyvitamin D3 in the chick. Holick, S.A., Holick, M.F., Tavela, T.E., Schnoes, H.K., DeLuca, H.F. J. Biol. Chem. (1976) [Pubmed]
  11. The comparative toxicity of vitamin D metabolites in the weanling mouse. Crocker, J.F., Muhtadie, S.F., Hamilton, D.C., Cole, D.E. Toxicol. Appl. Pharmacol. (1985) [Pubmed]
  12. Toxicologic studies of the hormonal form of vitamin D3: acute and subacute toxicity of 1alpha-hydroxycholecalciferol. Makita, T., Uotani, Y., Izawa, Y., Kawashima, H., Hashimoto, Y. Toxicol. Appl. Pharmacol. (1976) [Pubmed]
  13. Bone mineral density, bone metabolism and body composition of children with chronic renal failure, with and without growth hormone treatment. Boot, A.M., Nauta, J., de Jong, M.C., Groothoff, J.W., Lilien, M.R., van Wijk, J.A., Kist-van Holthe, J.E., Hokken-Koelega, A.C., Pols, H.A., de Muinck Keizer-Schrama, S.M. Clin. Endocrinol. (Oxf) (1998) [Pubmed]
  14. Treatment of hypercalcaemia with pamidronate in patients with end stage renal failure. Davenport, A., Goel, S., Mackenzie, J.C. Scand. J. Urol. Nephrol. (1993) [Pubmed]
  15. Effect of intermittent cyclical treatment with etidronate disodium (HEBP) and calcium plus alphacalcidol in postmenopausal osteoporosis. Shiota, E., Tsuchiya, K., Yamaoka, K., Kawano, O. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association. (2001) [Pubmed]
  16. Alphacalcidol in prevention of glucocorticoid-induced osteoporosis. Reginster, J.Y., de Froidmont, C., Lecart, M.P., Sarlet, N., Defraigne, J.O. Calcif. Tissue Int. (1999) [Pubmed]
  17. Hypertension in primary hyperparathyroidism--reduction of blood pressure by long-term treatment with vitamin D (alphacalcidol). A double-blind, placebo-controlled study. Lind, L., Wengle, B., Wide, L., Sörensen, O.H., Ljunghall, S. Am. J. Hypertens. (1988) [Pubmed]
  18. Crystallin gene expression in the process of lentoidogenesis in cultures of chicken lens epithelial cells. Sawada, K., Agata, K., Eguchi, G. Exp. Eye Res. (1992) [Pubmed]
  19. Early postmenopausal bone loss is prevented by estrogen and partially by 1alpha-OH-vitamin D3: therapeutic effects of estrogen and/or 1alpha-OH-vitamin D3. Gorai, I., Chaki, O., Taguchi, Y., Nakayama, M., Osada, H., Suzuki, N., Katagiri, N., Misu, Y., Minaguchi, H. Calcif. Tissue Int. (1999) [Pubmed]
  20. Differential response of calcium transport systems in laying hens to exogenous and endogenous changes in vitamin D status. Bar, A., Cohen, A., Eisner, U., Risenfeld, G., Hurwitz, S. J. Nutr. (1978) [Pubmed]
  21. Analysis of G protein alpha subunit mRNA abundance in preimplantation mouse embryos using a rapid, quantitative RT-PCR approach. Rambhatla, L., Patel, B., Dhanasekaran, N., Latham, K.E. Mol. Reprod. Dev. (1995) [Pubmed]
  22. The synthesis and activity in vitro of 25-masked 1alpha-hydroxylated vitamin D3 analogs. Napoli, J.L., Fivizzani, M.A., Hamstra, A.H., Schnoes, H.K., DeLuca, H.F., Stern, P.H. Steroids (1978) [Pubmed]
  23. A new active vitamin D analog, ED-71, causes increase in bone mass with preferential effects on bone in osteoporotic patients. Kubodera, N., Tsuji, N., Uchiyama, Y., Endo, K. J. Cell. Biochem. (2003) [Pubmed]
  24. Effect of kidney transplantation on bone. Kodras, K., Haas, M. Eur. J. Clin. Invest. (2006) [Pubmed]
  25. CYP3A4 is a human microsomal vitamin D 25-hydroxylase. Gupta, R.P., Hollis, B.W., Patel, S.B., Patrick, K.S., Bell, N.H. J. Bone Miner. Res. (2004) [Pubmed]
  26. The metabolism of [6-3H]1alpha, hydroxycholecalciferol to [6-3H]1alpha,25-dihydroxycholecalciferol in a patient with renal insufficiency. Holick, M.F., de Blanco, M.C., Clark, M.B., Henley, J.W., Neer, R.M., DeLuca, H.F., Potts, J.T. J. Clin. Endocrinol. Metab. (1977) [Pubmed]
  27. Is low plasma 25-(OH)vitamin D a major risk factor for hyperparathyroidism and Looser's zones independent of calcitriol? Ghazali, A., Fardellone, P., Pruna, A., Atik, A., Achard, J.M., Oprisiu, R., Brazier, M., Remond, A., Morinière, P., Garabedian, M., Eastwood, J., Fournier, A. Kidney Int. (1999) [Pubmed]
  28. The management of hypoparathyroidism with 1alpha-hydroxyvitamin D3. Heyburn, P.J., Peacock, M. Clin. Endocrinol. (Oxf) (1977) [Pubmed]
  29. Comparison of the efficacy of two injectable forms of vitamin D3 and oral one-alpha in treatment of secondary hyperparathyroidism in patients on maintenance hemodialysis. el-Reshaid, K., el-Reshaid, W., Sugathan, T., al-Mohannadi, S., Sivanandan, R. American journal of nephrology. (1997) [Pubmed]
  30. Osteopenia in genetically diabetic DB/DB mice and effects of 1alpha-hydroxyvitamin D3 on the osteopenia. Basic Research Group. Takeshita, N., Mutoh, S., Yamaguchi, I. Life Sci. (1995) [Pubmed]
  31. Growth inhibition and differentiation induction in human monoblastic leukaemia cells by 1alpha-hydroxyvitamin D derivatives and their enhancement by combination with hydroxyurea. Makishima, M., Okabe-Kado, J., Honma, Y. Br. J. Cancer (1998) [Pubmed]
  32. Induction of mouse beta integrin expression following transfection with human alpha 4 chain. Webb, D.L., Conrad, P.J., Ma, L., Blue, M.L. J. Cell. Biochem. (1996) [Pubmed]
  33. Prevention of corticosteroid-induced osteoporosis by alfacalcidol. Lakatos, P., Nagy, Z., Kiss, L., Horvath, C., Takacs, I., Foldes, J., Speer, G., Bossanyi, A. Zeitschrift für Rheumatologie. (2000) [Pubmed]
  34. Effect of 1,25-dihydroxycholecalciferol on glucose metabolism in gestational diabetes mellitus. Rudnicki, P.M., Mølsted-Pedersen, L. Diabetologia (1997) [Pubmed]
  35. Prevention of bone loss in cardiac transplant recipients. A comparison of biphosphonates and vitamin D. Van Cleemput, J., Daenen, W., Geusens, P., Dequeker, P., Van De Werf, F., VanHaecke, J. Transplantation (1996) [Pubmed]
  36. Bone loss after liver transplantation is not prevented by cyclical etidronate, calcium and alphacalcidol. The Liver Transplant Group, Groningen. Riemens, S.C., Oostdijk, A., van Doormaal, J.J., Thijn, C.J., Drent, G., Piers, D.A., Groen, E.W., Meerman, L., Slooff, M.J., Haagsma, E.B. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (1996) [Pubmed]
  37. The use of 1alpha-hydroxyvitamin D3 in the management of patients undergoing parathyroidectomy. Parsons, V., Jones, R., Weston, M., Lucas, P., Snowden, S., Keenan, J., Packham, D. Clin. Endocrinol. (Oxf) (1977) [Pubmed]
WikiGenes - Universities