- A high incidence of bleeding is observed in a trial to determine whether addition of metronidazole is needed with latamoxef for prophylaxis in colorectal surgery. Morris, D.L., Fabricius, P.J., Ambrose, N.S., Scammell, B., Burdon, D.W., Keighley, M.R. J. Hosp. Infect. (1984)