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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene.

Antibodies in sera from patients with adult T-cell leukemia-lymphoma or from healthy carriers of type I human T-cell leukemia virus (HTLV) recognize an antigen of approximately 42 kilodaltons ( p42) in cell lines infected with HTLV-I. Radiolabel sequence analysis of cyanogen bromide fragments of p42 led to the conclusion that this antigen is encoded in part by LOR, a conserved portion of the "X" region that is flanked by the envelope gene and the 3' long terminal repeat of HTLV-I. It is possible that this novel product mediates the unique transformation properties of the HTLV family.[1]

References

  1. Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene. Lee, T.H., Coligan, J.E., Sodroski, J.G., Haseltine, W.A., Salahuddin, S.Z., Wong-Staal, F., Gallo, R.C., Essex, M. Science (1984) [Pubmed]
 
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