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MeSH Review

Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated

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Disease relevance of Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated


High impact information on Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated


Chemical compound and disease context of Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated


Biological context of Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated


Anatomical context of Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated

  • Human T cell leukemia/lymphoma virus I infection and subsequent cloning of normal human B cells. Direct responsiveness of cloned cells to recombinant interleukin 2 by differentiation in the absence of enhanced proliferation [21].
  • HTLV antigens were present on endothelial syncytia passaged in culture for greater than 3 months as detected by an anti-p19 monoclonal antibody, which detects a core protein of HTLV-I, and by ATLL sera [22].
  • Sera and peripheral blood cells of an adult T-cell leukemia patient and several clinically normal members of his family from the northwest coast of Japan were examined for evidence of infection with human T-cell leukemia (lymphoma) virus (HTLV) [23].
  • A multilobulated nuclear appearance is an important diagnostic marker of ATLL, and we have now identified that the molecular mechanisms underlying these formations occur through microtubule rearrangement via phosphatidylinositol 3-kinase (PI3-kinase) activation by AILIM/ICOS signaling [24].
  • Seroreactivity to an envelope protein of human T-cell leukemia/lymphoma virus in patients with CD3- (natural killer) lymphoproliferative disease of granular lymphocytes [25].

Gene context of Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated


Analytical, diagnostic and therapeutic context of Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated


  1. Interferon alfa and zidovudine in adult T-cell leukemia-lymphoma. Lymphoma Study Group of the Japan Clinical Oncology Group. Tobinai, K., Kobayashi, Y., Shimoyama, M. N. Engl. J. Med. (1995) [Pubmed]
  2. Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene. Lee, T.H., Coligan, J.E., Sodroski, J.G., Haseltine, W.A., Salahuddin, S.Z., Wong-Staal, F., Gallo, R.C., Essex, M. Science (1984) [Pubmed]
  3. Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence? Longnecker, R. Adv. Cancer Res. (2000) [Pubmed]
  4. Expression of cellular homologues of retroviral onc genes in human hematopoietic cells. Westin, E.H., Wong-Staal, F., Gelmann, E.P., Dalla-Favera, R., Papas, T.S., Lautenberger, J.A., Eva, A., Reddy, E.P., Tronick, S.R., Aaronson, S.A., Gallo, R.C. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  5. Human T-cell growth factor (interleukin 2) and gamma-interferon genes: expression in human T-lymphotropic virus type III- and type I-infected cells. Arya, S.K., Gallo, R.C. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  6. Interferon alfa and zidovudine in adult T-cell leukemia-lymphoma. Pagano, J.S. N. Engl. J. Med. (1995) [Pubmed]
  7. Treatment of adult T-cell leukemia-lymphoma with a combination of interferon alfa and zidovudine. Gill, P.S., Harrington, W., Kaplan, M.H., Ribeiro, R.C., Bennett, J.M., Liebman, H.A., Bernstein-Singer, M., Espina, B.M., Cabral, L., Allen, S. N. Engl. J. Med. (1995) [Pubmed]
  8. The structure, function, and expression of interleukin-2 receptors on normal and malignant lymphocytes. Waldmann, T.A. Science (1986) [Pubmed]
  9. The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells. Imura, A., Hori, T., Imada, K., Ishikawa, T., Tanaka, Y., Maeda, M., Imamura, S., Uchiyama, T. J. Exp. Med. (1996) [Pubmed]
  10. Transactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by human T lymphotropic virus type 1 tax: a potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia. Kim, S.J., Kehrl, J.H., Burton, J., Tendler, C.L., Jeang, K.T., Danielpour, D., Thevenin, C., Kim, K.Y., Sporn, M.B., Roberts, A.B. J. Exp. Med. (1990) [Pubmed]
  11. The recombinant immunotoxin anti-Tac(Fv)-Pseudomonas exotoxin 40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia. Kreitman, R.J., Chaudhary, V.K., Waldmann, T., Willingham, M.C., FitzGerald, D.J., Pastan, I. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  12. HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells. Satou, Y., Yasunaga, J., Yoshida, M., Matsuoka, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  13. Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element. Hiraiwa, N., Yabuta, T., Yoritomi, K., Hiraiwa, M., Tanaka, Y., Suzuki, T., Yoshida, M., Kannagi, R. Blood (2003) [Pubmed]
  14. New therapeutic effects of retinoid for adult T-cell leukemia. Maeda, Y., Miyatake, J., Sono, H., Sumimoto, Y., Matsuda, M., Horiuchi, F., Tatsumi, Y., Irimajiri, K., Horiuchi, A. Blood (1996) [Pubmed]
  15. Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with Yttrium-90-labeled anti-Tac. Waldmann, T.A., White, J.D., Carrasquillo, J.A., Reynolds, J.C., Paik, C.H., Gansow, O.A., Brechbiel, M.W., Jaffe, E.S., Fleisher, T.A., Goldman, C.K., Top, L.E., Bamford, R., Zaknoen, E., Roessler, E., Kasten-Sportes, C., England, R., Litou, H., Johnson, J.A., Jackson-White, T., Manns, A., Hanchard, B., Junghans, R.P., Nelson, D.L. Blood (1995) [Pubmed]
  16. Deregulation of interleukin-2 receptor gene expression in HTLV-I-induced adult T-cell leukemia. Krönke, M., Leonard, W.J., Depper, J.M., Greene, W.C. Science (1985) [Pubmed]
  17. Constitutive expression of parathyroid hormone-related protein gene in human T cell leukemia virus type 1 (HTLV-1) carriers and adult T cell leukemia patients that can be trans-activated by HTLV-1 tax gene. Watanabe, T., Yamaguchi, K., Takatsuki, K., Osame, M., Yoshida, M. J. Exp. Med. (1990) [Pubmed]
  18. APO-1-induced apoptosis of leukemia cells from patients with adult T-cell leukemia. Debatin, K.M., Goldman, C.K., Waldmann, T.A., Krammer, P.H. Blood (1993) [Pubmed]
  19. Leukemic cells from some adult T-cell leukemia patients proliferate in response to interleukin-4. Uchiyama, T., Kamio, M., Kodaka, T., Tamori, S., Fukuhara, S., Amakawa, R., Uchino, H., Araki, K. Blood (1988) [Pubmed]
  20. Cytogenetic analysis and clinical significance in adult T-cell leukemia/lymphoma: a study of 50 cases from the human T-cell leukemia virus type-1 endemic area, Nagasaki. Itoyama, T., Chaganti, R.S., Yamada, Y., Tsukasaki, K., Atogami, S., Nakamura, H., Tomonaga, M., Ohshima, K., Kikuchi, M., Sadamori, N. Blood (2001) [Pubmed]
  21. Human T cell leukemia/lymphoma virus I infection and subsequent cloning of normal human B cells. Direct responsiveness of cloned cells to recombinant interleukin 2 by differentiation in the absence of enhanced proliferation. Tomita, S., Ambrus, J.L., Volkman, D.J., Longo, D.L., Mitsuya, H., Reitz, M.S., Fauci, A.S. J. Exp. Med. (1985) [Pubmed]
  22. Infection of human endothelial cells by human T-cell leukemia virus type I. Hoxie, J.A., Matthews, D.M., Cines, D.B. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  23. High incidence of human type-C retrovirus (HTLV) in family members of a HTLV-positive Japanese T-cell leukemia patient. Sarin, P.S., Aoki, T., Shibata, A., Ohnishi, Y., Aoyagi, Y., Miyakoshi, H., Emura, I., Kalyanaraman, V.S., Robert-Guroff, M., Popovic, M., Sarngadharan, M., Nowell, P.C., Gallo, R.C. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  24. Alteration of phosphatidylinositol 3-kinase cascade in the multilobulated nuclear formation of adult T cell leukemia/lymphoma (ATLL). Fukuda, R., Hayashi, A., Utsunomiya, A., Nukada, Y., Fukui, R., Itoh, K., Tezuka, K., Ohashi, K., Mizuno, K., Sakamoto, M., Hamanoue, M., Tsuji, T. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  25. Seroreactivity to an envelope protein of human T-cell leukemia/lymphoma virus in patients with CD3- (natural killer) lymphoproliferative disease of granular lymphocytes. Loughran, T.P., Hadlock, K.G., Yang, Q., Perzova, R., Zambello, R., Semenzato, G., Foung, S.K., Poiesz, B.J. Blood (1997) [Pubmed]
  26. A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Burton, J.D., Bamford, R.N., Peters, C., Grant, A.J., Kurys, G., Goldman, C.K., Brennan, J., Roessler, E., Waldmann, T.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  27. Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins. Takemoto, S., Mulloy, J.C., Cereseto, A., Migone, T.S., Patel, B.K., Matsuoka, M., Yamaguchi, K., Takatsuki, K., Kamihira, S., White, J.D., Leonard, W.J., Waldmann, T., Franchini, G. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  28. Increased chemokine receptor CCR7/EBI1 expression enhances the infiltration of lymphoid organs by adult T-cell leukemia cells. Hasegawa, H., Nomura, T., Kohno, M., Tateishi, N., Suzuki, Y., Maeda, N., Fujisawa, R., Yoshie, O., Fujita, S. Blood (2000) [Pubmed]
  29. p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14(ARF)-MDM2 loop in ex vivo and cultured adult T-cell leukemia/lymphoma cells. Takemoto, S., Trovato, R., Cereseto, A., Nicot, C., Kislyakova, T., Casareto, L., Waldmann, T., Torelli, G., Franchini, G. Blood (2000) [Pubmed]
  30. Interleukin 2 receptor (Tac antigen) expression in HTLV-I-associated adult T-cell leukemia. Waldmann, T.A., Longo, D.L., Leonard, W.J., Depper, J.M., Thompson, C.B., Krönke, M., Goldman, C.K., Sharrow, S., Bongiovanni, K., Greene, W.C. Cancer Res. (1985) [Pubmed]
  31. Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related. Noma, T., Nakakubo, H., Sugita, M., Kumagai, S., Maeda, M., Shimizu, A., Honjo, T. J. Exp. Med. (1989) [Pubmed]
  32. Increasing methylation of the CDKN2A gene is associated with the progression of adult T-cell leukemia. Nosaka, K., Maeda, M., Tamiya, S., Sakai, T., Mitsuya, H., Matsuoka, M. Cancer Res. (2000) [Pubmed]
  33. Detection of HTLV-1 by polymerase chain reaction in situ hybridization in adult T-cell leukemia/lymphoma. Setoyama, M., Kerdel, F.A., Elgart, G., Kanzaki, T., Byrnes, J.J. Am. J. Pathol. (1998) [Pubmed]
  34. CD40 ligand is constitutively expressed in a subset of T cell lymphomas and on the microenvironmental reactive T cells of follicular lymphomas and Hodgkin's disease. Carbone, A., Gloghini, A., Gruss, H.J., Pinto, A. Am. J. Pathol. (1995) [Pubmed]
  35. Identification of two new HLA-A*1101-restricted tax epitopes recognized by cytotoxic T lymphocytes in an adult T-cell leukemia patient after hematopoietic stem cell transplantation. Harashima, N., Tanosaki, R., Shimizu, Y., Kurihara, K., Masuda, T., Okamura, J., Kannagi, M. J. Virol. (2005) [Pubmed]
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