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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Some patients with cerebral aneurysms are deficient in type III collagen.

Polyacrylamide gel electrophoresis of pepsin-digested skin biopsy specimens and carboxymethyl cellulose chromatography of radioactively labelled collagens produced by cultured fibroblasts demonstrated that 7 of 12 patients with congenital cerebral aneurysms were type III collagen deficient. This suggests that some cerebral aneurysms resemble various inherited defects of connective tissue-i.e., Ehlers-Danlos syndrome type IV-in which type III collagen deficiency causes arterial fragility.[1]

References

  1. Some patients with cerebral aneurysms are deficient in type III collagen. Pope, F.M., Nicholls, A.C., Narcisi, P., Bartlett, J., Neil-Dwyer, G., Doshi, B. Lancet (1981) [Pubmed]
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