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Chemical Compound Review

L-Glucose     2,3,4,5,6-pentahydroxyhexanal

Synonyms: Cerelose, Glucolin, Cartose, Dextropur, Dextrosol, ...
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Disease relevance of D-glucose


High impact information on D-glucose


Biological context of D-glucose

  • 2. L-Rhamnose, L-mannose and L-lyxose were inducers of the sugar-H+ symport and of L-[14C]rhamnose transport activity [8].
  • Despite these analogies between both the respective fate of D-glucose and D-fructose and the reciprocal metabolic effects of the two hexoses in islets from control and STZ rats, the secretory response to the ketohexose in islets from STZ rats was preferentially suppressed, relative to that evoked by the aldohexose [9].
  • The precursor was prepared by selective acetylation and triflation of L-mannose [10].
  • D-glucose, although slightly decreasing D-[5-(3)H]fructose utilization, augmented the oxidation of the ketohexose, indicating that the aldohexose stimulates preferentially the oxidative, as distinct from anaerobic, modality of glycolysis [11].

Anatomical context of D-glucose


Associations of D-glucose with other chemical compounds


Gene context of D-glucose

  • The Ta0754 gene product exhibited aldohexose dehydrogenase activity, and the Ta0191 gene product exhibited weak 2-deoxyglucose dehydrogenase activity [22].
  • (2)H Equilibrium isotope effects (EIEs) on aldohexose anomerization were measured in D-galactose 3 and D-talose 8 selectively (13)C- and (2)H-labeled at C1 and H1 [17].
  • Analysis of bacterial glucose dehydrogenase homologs from thermoacidophilic archaeon Thermoplasma acidophilum: finding and characterization of aldohexose dehydrogenase [22].
  • As confirmed by transepithelial potential difference (PD) measurements, there is a distinct fructose transporter that does not evoke a PD, along with one or more aldohexose transporters that do evoke a PD [23].

Analytical, diagnostic and therapeutic context of D-glucose


  1. Aldohexose dehydrogenase from Gluconobacter cerinus-1. Avigad, G., Englard, S. Meth. Enzymol. (1975) [Pubmed]
  2. Redox-related cytotoxic responses to different casein glycation products in Caco-2 and int-407 cells. Jing, H., Kitts, D.D. J. Agric. Food Chem. (2004) [Pubmed]
  3. Antioxidants improve impaired insulin-mediated glucose uptake and prevent migration and proliferation of cultured rabbit coronary smooth muscle cells induced by high glucose. Yasunari, K., Kohno, M., Kano, H., Yokokawa, K., Minami, M., Yoshikawa, J. Circulation (1999) [Pubmed]
  4. Insulin binding and insulin action in cultured fibroblasts: significant differences between a phosphoglucose isomerase-deficient mutant and the parental strain. Wilson, C., Peterson, S.W., Ullrey, D.B., Kalckar, H.M. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  5. Extracellular matrix of cultured bovine aortic endothelial cells contains functionally active type 1 plasminogen activator inhibitor. Mimuro, J., Schleef, R.R., Loskutoff, D.J. Blood (1987) [Pubmed]
  6. Anomeric specificity of the stimulatory effect of D-glucose on D-fructose phosphorylation by human liver glucokinase. Jijakli, H., Courtois, P., Zhang, H.X., Sener, A., Malaisse, W.J. J. Biol. Chem. (2003) [Pubmed]
  7. Enzymatic assay of D-mannose in serum. Etchison, J.R., Freeze, H.H. Clin. Chem. (1997) [Pubmed]
  8. Proton-linked L-rhamnose transport, and its comparison with L-fucose transport in Enterobacteriaceae. Muiry, J.A., Gunn, T.C., McDonald, T.P., Bradley, S.A., Tate, C.G., Henderson, P.J. Biochem. J. (1993) [Pubmed]
  9. Metabolic and secretory response to D-fructose in pancreatic islets from adult rats injected with streptozotocin during the neonatal period. Scruel, O., Giroix, M.H., Sener, A., Portha, B., Malaisse, W.J. Mol. Genet. Metab. (1999) [Pubmed]
  10. Synthesis of 2-[18F]fluoro-2-deoxy-L-glucose and positron emission tomography studies in monkeys. Meng, J., Elmaleh, D.R., Jyawook, S., Weiss, S., Alpert, N.M., Babich, J.W., Tompkins, R.G., Fischman, A.J. Nucl. Med. Biol. (1994) [Pubmed]
  11. Hexose metabolism in pancreatic islets: effect of D-glucose upon D-fructose metabolism. Scruel, O., Sener, A., Malaisse, W.J. Mol. Cell. Biochem. (1999) [Pubmed]
  12. Fructose 2,6-bisphosphate and glucose 1,6-bisphosphate in rabbit erythroid cells during differentiation. Gallego, C., Bartrons, R., Carreras, J. FEBS Lett. (1987) [Pubmed]
  13. Role of monocyte fucose-receptors in T-cell fibronectin activity. Donson, J., Mandy, K., Feng, Z.H., Mandy, S., Brown, E.J., Godfrey, H.P. Immunology (1991) [Pubmed]
  14. 2,3-Bisphosphoglycerate, fructose, 2,6-bisphosphate and glucose 1,6-bisphosphate during maturation of reticulocytes with low 2,3-bisphosphoglycerate content. Gallego, C., Carreras, J. Mol. Cell. Biochem. (1990) [Pubmed]
  15. Partial purification and characterization of an aldohexose 1-P phosphatase from pig skeletal muscle. Cussó, R., Bassols, A.M., Carreras, J. Biochim. Biophys. Acta (1987) [Pubmed]
  16. Impaired glucose homeostasis during postimplantation pregnancy in the mouse following acute exposure to ethanol, with particular reference to the uterus and embryo. Murdoch, R.N., Simm, B. Biochem. Med. Metab. Biol. (1992) [Pubmed]
  17. Acyclic forms of [1-(13)C]aldohexoses in aqueous solution: quantitation by (13)C NMR and deuterium isotope effects on tautomeric equilibria. Zhu, Y., Zajicek, J., Serianni, A.S. J. Org. Chem. (2001) [Pubmed]
  18. Response of rat small intestinal active aldohexose transport to elevation of mucosal cyclic AMP by forskolin and 3-isobutyl-1-methylxanthine in vitro. Reymann, A., Braun, W., Woermann, C. Naunyn Schmiedebergs Arch. Pharmacol. (1985) [Pubmed]
  19. Enzymatic determination of unbound D-mannose in serum. Pitkänen, E., Pitkänen, O., Uotila, L. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. (1997) [Pubmed]
  20. Lectin histochemistry of the olfactory surface in two teleostean fishes. Pastor, L.M., Graña, L., Frutos, M.J., Villaverde, R., Ramos, D. Acta Histochem. (1991) [Pubmed]
  21. Crystallization and preliminary crystallographic analysis of NAD+-preferring aldohexose dehydrogenase from the thermoacidophilic archaeon Thermoplasma acidophilum. Yasutake, Y., Nishiya, Y., Tamura, N., Tamura, T. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2006) [Pubmed]
  22. Analysis of bacterial glucose dehydrogenase homologs from thermoacidophilic archaeon Thermoplasma acidophilum: finding and characterization of aldohexose dehydrogenase. Nishiya, Y., Tamura, N., Tamura, T. Biosci. Biotechnol. Biochem. (2004) [Pubmed]
  23. Comparison of different dietary sugars as inducers of intestinal sugar transporters. Solberg, D.H., Diamond, J.M. Am. J. Physiol. (1987) [Pubmed]
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