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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Gastrointestinal secretory, motor, circulatory, and metabolic effects of prosomatostatin.

This study compares the gastrointestinal effects of somatostatin ( SS) and its putative prohormone, prosomatostatin (Pro- SS), a 28-amino acid peptide isolated from the hypothalamus and the gut, in conscious dogs with chronic gastric and pancreatic fistulae. Pro-Ss suppressed the release of serum gastrin, insulin, and pancreatic polypeptide that occurs in response to feeding a meat meal in a manner similar to that seen with SS. However, in contrast to SS, which strongly reduced intestinal blood flow and oxygen consumption and stimulated intestinal motility, Pro- SS, at the doses tested, had no influence on mesenteric circulation, oxygen uptake, and intestinal motility. We conclude that Pro- SS mimics most of the gastrointestinal secretory actions of SS, but does not exhibit the intestinal circulatory, metabolic, and motor effects of SS.[1]

References

  1. Gastrointestinal secretory, motor, circulatory, and metabolic effects of prosomatostatin. Konturek, S.J., Tasler, J., Jaworek, J., Pawlik, W., Walus, K.M., Schusdziarra, V., Meyers, C.A., Coy, D.H., Schally, A.V. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
 
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