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MeSH Review

Gastrointestinal Motility

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Disease relevance of Gastrointestinal Motility


Psychiatry related information on Gastrointestinal Motility


High impact information on Gastrointestinal Motility


Chemical compound and disease context of Gastrointestinal Motility


Biological context of Gastrointestinal Motility


Anatomical context of Gastrointestinal Motility


Associations of Gastrointestinal Motility with chemical compounds


Gene context of Gastrointestinal Motility

  • We hypothesised that peripheral administration of alpha-helical CRH (alphahCRH), a non-selective CRH receptor antagonist, would improve gastrointestinal motility, visceral perception, and negative mood in response to gut stimulation in IBS patients [32].
  • It is likely that CCK has a physiological role not only in the stimulation of pancreatic and biliary secretions but also in the regulation of gastrointestinal motility [33].
  • High expression of TRPV1 has been detected in several inflammatory diseases of the colon and ileum, whereas neuropeptides released upon sensory nerve stimulation triggered by TRPV1 activation seem to play a role in intestinal motility disorders [34].
  • Studies have shown that neuropeptide Y, peptide YY, and PP increased gastrointestinal motility [35].
  • Although ghrelin is involved in several other responses such as stress and intestinal motility, its potential role in intestinal inflammation is not clear [36].

Analytical, diagnostic and therapeutic context of Gastrointestinal Motility


  1. Effect of erythromycin on gastric motility in controls and in diabetic gastroparesis. Tack, J., Janssens, J., Vantrappen, G., Peeters, T., Annese, V., Depoortere, I., Muls, E., Bouillon, R. Gastroenterology (1992) [Pubmed]
  2. Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome. Fukudo, S., Nomura, T., Hongo, M. Gut (1998) [Pubmed]
  3. Clinical pharmacokinetics of drugs used in the treatment of gastrointestinal diseases (Part I). Lauritsen, K., Laursen, L.S., Rask-Madsen, J. Clinical pharmacokinetics. (1990) [Pubmed]
  4. Purified Shigella enterotoxin does not alter intestinal motility. Fernandez, A., Sninsky, C.A., O'Brien, A.D., Clench, M.H., Mathias, J.R. Infect. Immun. (1984) [Pubmed]
  5. Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk. Bouchard, G., Johnson, D., Carver, T., Paigen, B., Carey, M.C. J. Lipid Res. (2002) [Pubmed]
  6. Prostaglandin E2: a neuromodulator in the central control of gastrointestinal motility and feeding behavior by calcitonin. Fargeas, M.J., Fioramonti, J., Buéno, L. Science (1984) [Pubmed]
  7. Intestinal motility during ontogeny and intestinal pseudo-obstruction in children. Milla, P.J. Pediatr. Clin. North Am. (1996) [Pubmed]
  8. Effects of psychological stress on small intestinal motility and expression of cholecystokinin and vasoactive intestinal polypeptide in plasma and small intestine in mice. Cao, S.G., Wu, W.C., Han, Z., Wang, M.Y. World J. Gastroenterol. (2005) [Pubmed]
  9. Effect of octreotide on intestinal motility and bacterial overgrowth in scleroderma. Soudah, H.C., Hasler, W.L., Owyang, C. N. Engl. J. Med. (1991) [Pubmed]
  10. Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa. Rio, M.C., Bellocq, J.P., Daniel, J.Y., Tomasetto, C., Lathe, R., Chenard, M.P., Batzenschlager, A., Chambon, P. Science (1988) [Pubmed]
  11. Central regulation of intestinal motility by somatostatin and cholecystokinin octapeptide. Bueno, L., Ferre, J.P. Science (1982) [Pubmed]
  12. GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathway. Anitha, M., Gondha, C., Sutliff, R., Parsadanian, A., Mwangi, S., Sitaraman, S.V., Srinivasan, S. J. Clin. Invest. (2006) [Pubmed]
  13. Systematic review: serotonergic modulators in the treatment of irritable bowel syndrome--influence on psychiatric and gastrointestinal symptoms. Kilkens, T.O., Honig, A., Rozendaal, N., Van Nieuwenhoven, M.A., Brummer, R.J. Aliment. Pharmacol. Ther. (2003) [Pubmed]
  14. Double-blind study of an alpha 2 agonist in the treatment of irritable bowel syndrome. Prior, A., Wilson, K.M., Whorwell, P.J. Aliment. Pharmacol. Ther. (1988) [Pubmed]
  15. Epidural anesthesia accelerates the recovery of postischemic bowel motility in the rat. Udassin, R., Eimerl, D., Schiffman, J., Haskel, Y. Anesthesiology (1994) [Pubmed]
  16. Pharmacological profile of PD 117302, a selective kappa-opioid agonist. Leighton, G.E., Johnson, M.A., Meecham, K.G., Hill, R.G., Hughes, J. Br. J. Pharmacol. (1987) [Pubmed]
  17. Mebeverine alters small bowel motility in irritable bowel syndrome. Evans, P.R., Bak, Y.T., Kellow, J.E. Aliment. Pharmacol. Ther. (1996) [Pubmed]
  18. Gdnf haploinsufficiency causes Hirschsprung-like intestinal obstruction and early-onset lethality in mice. Shen, L., Pichel, J.G., Mayeli, T., Sariola, H., Lu, B., Westphal, H. Am. J. Hum. Genet. (2002) [Pubmed]
  19. Gastrointestinal secretory, motor, circulatory, and metabolic effects of prosomatostatin. Konturek, S.J., Tasler, J., Jaworek, J., Pawlik, W., Walus, K.M., Schusdziarra, V., Meyers, C.A., Coy, D.H., Schally, A.V. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  20. Effect of somatostatin and atropine infusion on intestinal transit time and fructose absorption in the perfused human jejunum. Krejs, G.J. Diabetes (1984) [Pubmed]
  21. A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis. Baggio, L.L., Huang, Q., Brown, T.J., Drucker, D.J. Diabetes (2004) [Pubmed]
  22. Clinical pharmacokinetics in patients with spinal cord injuries. Segal, J.L., Brunnemann, S.R. Clinical pharmacokinetics. (1989) [Pubmed]
  23. Effect of enteric pacing on intestinal motility and hormone secretion in dogs with short bowel. Reiser, S.B., Schusdziarra, V., Bollschweiler, E., Hölscher, A.H., Siewert, J.R. Gastroenterology (1991) [Pubmed]
  24. Role of cholecystokinin in regulation of gastrointestinal motor functions. Meyer, B.M., Werth, B.A., Beglinger, C., Hildebrand, P., Jansen, J.B., Zach, D., Rovati, L.C., Stalder, G.A. Lancet (1989) [Pubmed]
  25. Mast cell heterogeneity: effects of neuroenteric peptides on histamine release. Shanahan, F., Denburg, J.A., Fox, J., Bienenstock, J., Befus, D. J. Immunol. (1985) [Pubmed]
  26. Influence of ghrelin on interdigestive gastrointestinal motility in humans. Tack, J., Depoortere, I., Bisschops, R., Delporte, C., Coulie, B., Meulemans, A., Janssens, J., Peeters, T. Gut (2006) [Pubmed]
  27. Improvement of gastric emptying in diabetic gastroparesis by erythromycin. Preliminary studies. Janssens, J., Peeters, T.L., Vantrappen, G., Tack, J., Urbain, J.L., De Roo, M., Muls, E., Bouillon, R. N. Engl. J. Med. (1990) [Pubmed]
  28. Determinants of response to a prokinetic agent in neuropathic chronic intestinal motility disorder. Camilleri, M., Balm, R.K., Zinsmeister, A.R. Gastroenterology (1994) [Pubmed]
  29. Plasma motilin concentration and interdigestive migrating motor complex in diabetic gastroparesis: effect of metoclopramide. Achem-Karam, S.R., Funakoshi, A., Vinik, A.I., Owyang, C. Gastroenterology (1985) [Pubmed]
  30. Effect of substance P on intestinal muscle. Yau, W.M. Gastroenterology (1978) [Pubmed]
  31. Dual effect of trimebutine on contractility of the guinea pig ileum via the opioid receptors. Taniyama, K., Sano, I., Nakayama, S., Matsuyama, S., Takeda, K., Yoshihara, C., Tanaka, C. Gastroenterology (1991) [Pubmed]
  32. Effect of a corticotropin releasing hormone receptor antagonist on colonic sensory and motor function in patients with irritable bowel syndrome. Sagami, Y., Shimada, Y., Tayama, J., Nomura, T., Satake, M., Endo, Y., Shoji, T., Karahashi, K., Hongo, M., Fukudo, S. Gut (2004) [Pubmed]
  33. Involvement of endogenous CCK and CCK1 receptors in colonic motor function. Varga, G., Bálint, A., Burghardt, B., D'Amato, M. Br. J. Pharmacol. (2004) [Pubmed]
  34. Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function. Geppetti, P., Trevisani, M. Br. J. Pharmacol. (2004) [Pubmed]
  35. Evidence of a specific pancreatic polypeptide receptor in rat arterial smooth muscle. Barrios, V.E., Sun, J., Douglass, J., Toombs, C.F. Peptides (1999) [Pubmed]
  36. Ghrelin stimulates interleukin-8 gene expression through protein kinase C-mediated NF-kappaB pathway in human colonic epithelial cells. Zhao, D., Zhan, Y., Zeng, H., Moyer, M.P., Mantzoros, C.S., Pothoulakis, C. J. Cell. Biochem. (2006) [Pubmed]
  37. Effects of oral erythromycin on fasting and postprandial antroduodenal motility in patients with type I diabetes, measured with an ambulatory manometric technique. Samsom, M., Jebbink, R.J., Akkermans, L.M., Bravenboer, B., vanBerge-Henegouwen, G.P., Smout, A.J. Diabetes Care (1997) [Pubmed]
  38. The interaction between prostaglandin E1 and delta 9-tetrahydrocannabinol on intestinal motility and on the abdominal constriction response in the mouse. Jackson, D.M., Malor, R., Chesher, G.B., Starmer, G.A., Welburn, P.J., Bailey, R. Psychopharmacologia. (1976) [Pubmed]
  39. Gastric but not duodenal motor effects of oral erythromycin are dose related. Mathis, C., Malbert, C.H. Neurogastroenterol. Motil. (1995) [Pubmed]
  40. Pancreatic spasmolytic polypeptide (PSP): III. Pharmacology of a new porcine pancreatic polypeptide with spasmolytic and gastric acid secretion inhibitory effects. Jørgensen, K.D., Diamant, B., Jørgensen, K.H., Thim, L. Regul. Pept. (1982) [Pubmed]
  41. Effect of premedication with diazepam, morphine or nalbuphine on gastrointestinal motility after surgery. Shah, M., Rosen, M., Vickers, M.D. British journal of anaesthesia. (1984) [Pubmed]
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