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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Holmdahl, G. et al.

The effect of timolol maleate on the disruption of the blood-aqueous barrier in the rabbit eye.

A disruption of the blood-aqueous barrier in rabbit eyes was elicited by use of topical prostaglandin E2(PGE2), infrared irradiation of the iris, or by subcutaneous alpha-melanocyte-stimulating hormone (alpha-MSH). The aqueous flare provoked was measured quantitatively with a photoelectric instrument. The effect of the (topical) beta-adrenergic antagonist timolol maleate on the breakdown of the blood-aqueous barrier was tested. Timolol applied topically in very large doses had no effect on exogenously administered PGE2. However, even in a very small concentration applied topically, timolol reduced the flare response to both infrared irradiation and alpha-MSH. These results support the theory that the effect of alpha-MSH and infrared irradiation on the blood-aqueous barrier is dependent on intact beta-adrenergic receptor sites.[1]

References

The effect of timolol maleate on the disruption of the blood-aqueous barrier in the rabbit eye. Holmdahl, G., Bengtsson, E. Invest. Ophthalmol. Vis. Sci. (1981) [Pubmed]

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