Evaluation of phenoxetol-chlorhexidine cream as a prophylactic antibacterial agent in burns.
A controlled clinical trial was conducted to compare the value of a cream containing 2% phenoxetol and 0.2% chlorhexidine as a prophylactic agent against wound infection in patients with burns affecting up to 15% total body surface area. The acquisition of bacteria was similar in the two treatment groups but the incidence of Staphylococcus aureus in the burns treated with phenoxetol-chlorhexidine cream significantly lower. The incidence of gram-negative bacilli was low in the two treatment groups, and no wound yielded Pseudomonas aeruginosa. Unlike preparations containing silver, phenoxetol-chlorhexidine does not cause electrolyte imbalance or stain materials with which it comes into contact, and it did not produce adverse effects during this trial.[1]References
- Evaluation of phenoxetol-chlorhexidine cream as a prophylactic antibacterial agent in burns. Lawrence, J.C., Cason, J.S., Kidson, A. Lancet (1982) [Pubmed]
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