Disease relevance of Glycol monophenyl ether

• The effects of phenoxyethanol, chlorhexidine and a mixture of both on subgingival plaque samples from 44 patients with chronic periodontitis were investigated in vitro [1].
• Phenoxyethanol-induced urticaria [2].
• A strictly anaerobic gram-positive, rod-shaped bacterium, strain LuPhet1, was isolated from sewage sludge with phenoxyethanol as sole carbon and energy source, and was assigned to the genus Acetobacterium [3].
• The action of phenoxyethanol upon respiration and dehydrogenase enzyme systems in Escherichia coli [proceedings] [4].
• Phenoxyethanol has activity against a range of bacteria, including Pseudomonas aeruginosa, and is absorbed by intact skin [5].

High impact information on Glycol monophenyl ether

• Zebrafish larvae, ranging in age from 3 to 21 days postfertilization, were prevented from ventilating their gills and forced to rely on cutaneous processes by exposing them to one of two anaesthetics (tricaine methanesulphonate or phenoxyethanol) or by embedding their gills in agar [6].
• Creams based on the formula for Aqueous Cream BP were produced by hand-mixing and mechanical mixing, with and without the inclusion of the preservative phenoxyethanol [7].
• Methyl-4-hydroxy-benzoate and 2-phenoxyethanol as well as the irritants SLS and dithranol failed to induce a significant effect in this assay [8].
• We conclude that, in contrast to alcohol-based antiseptics, an aqueous solution of 0.1% octenidine and 2-phenoxyethanol does not cause major skin damage in premature newborn infants <27 weeks' gestation [9].
• Effects of phenoxyethanol on the innate immune system of gilthead seabream (Sparus aurata L.) exposed to crowding stress [10].

Chemical compound and disease context of Glycol monophenyl ether

• An in vitro study on the effect of benzoyl peroxide 20%, gentamicin and phenoxyethanol on Staphylococcus aureus, Pseudomonas aeruginosa and Proteus species [11].
• The effects of concentrations of 2-phenoxyethanol of negligible bactericidal activity upon the rates of biosynthetic assimilation by Escherichia coli, of 14C-thymidine, 14C-uracil, 14C-phenylalanine and 14C-glucose, were assessed [12].
• Concentrations of phenoxyethanol which retarded the growth rate of Escherichia coli NCTC 5933 in nutrient broth, stimulated the rates of respiration and total oxygen uptake of cell suspensions with glucose as carbon source, and were able to dissipate artificially induced membrane proton gradients [13].
• Three cases of contact allergy after chemical burns from methylchloroisothiazolinone/methylisothiazolinone: one with concomitant allergy to methyldibromoglutaronitrile/phenoxyethanol [14].
• Twelve cadavers embalmed with four different formalin-containing embalming fluids were used (n = 3 per fluid): (1) formalin mix (10% formalin); (2) Dunedin mix (an alcohol-based fluid containing phenol); (3) Michigan mix (a water-based fluid); and (4) phenoxyethanol mix (an alcohol-based fluid containing phenoxyethanol) [15].

Biological context of Glycol monophenyl ether

• When the effects of anaesthesia on crowded fish were analysed, the results pointed to a slight reduction in stress as a result of the sedative dose of phenoxyethanol (lower increase in cortisol and lower reduction in phagocytosis) [10].
• In the most immature newborn (gestational age 23 6/7 weeks), a transient erythematous reaction was observed following application of the octenidine/phenoxyethanol solution prior to umbilical vessel catheterization [9].
• The new methods employ faster, less toxic embalming and reduced or eliminated phenoxyethanol immersions [16].
• Effect of 2-phenoxyethanol upon RNA, DNA and protein biosynthesis in Escherichia coli NCTC 5933 [12].
• In addition to its previously observed roles in inhibiting oxidative phosphorylation and TCA cycle enzymes, it is suggested that 2-phenoxyethanol can exert a more direct inhibitory action upon DNA and RNA biosynthesis and possibly on protein biosynthesis [12].

Anatomical context of Glycol monophenyl ether

• It is suggested that phenoxyethanol may be a suitable alternative to the cationic agents for use in antiseptic policies for bladder management of urinary tract infections with Providencia stuartii [17].
• Examination of rabbit fetuses indicated that, at the dosages tested, 2-phenoxyethanol was not embryotoxic, fetotoxic, or teratogenic [18].
• The immediate and delayed effects of 2-phenoxyethanol on the central nervous system resemble those of the other organic solvents [19].

Associations of Glycol monophenyl ether with other chemical compounds

• Further patch tests with Euxyl K 400 0.5% pet. and phenoxyethanol 5% pet. were performed in 11 patients [20].
• Phenoxyethanol as a nontoxic substitute for formaldehyde in long-term preservation of human anatomical specimens for dissection and demonstration purposes [21].
• Isolated dehydrogenase enzymes of the tricarboxylic acid cycle in cell-free preparations were unaffected by high concentrations of phenoxyethanol (0.8% w/v) with the exception of malate dehydrogenase which was inhibited in extracts to extents similar to those of malate oxidation by intact bacteria [22].

Gene context of Glycol monophenyl ether

• Generalized eczema in an 18-month-old boy due to phenoxyethanol in DPT vaccine [23].

Analytical, diagnostic and therapeutic context of Glycol monophenyl ether

• A positive patch test to phenoxyethanol was detected in 1 of them [20].
• The identification of 2-phenoxyethanol in ballpoint inks using gas chromatography/mass spectrometry--relevance to ink dating [24].
• A high-performance liquid chromatographic (HPLC) method for the determination of oxolinic acid (OA) in the plasma of seabass (Dicentrarchus labrax) anaesthetized with 2-phenoxyethanol is described [25].

References